羧甲基-β-环糊精的溶血作用及对槲皮素的增溶作用  

Synthesis of carboxymethyl-β-cyclodextrin and its hemolysis and solubilization

作　　者：宋全道[1] 丁易 李新民 米广太[1] 

机构地区：[1]山东大学药学院物理化学教研室,山东济南250012 [2]济南市科技信息研究所,山东济南25001 [3]莱阳中医药学校,山东莱阳265200

出　　处：《山东大学学报（医学版）》2005年第2期166-169,共4页Journal of Shandong University:Health Sciences

摘　　要：目的:研究羧甲基-β-环糊精的溶血作用和对槲皮素的增溶作用。方法:用红外光谱、13C-NMR波谱等方法鉴定合成的羧甲基-β-环糊精;用人全血中分离的红细胞测定其在体外的溶血作用;用紫外分光光度法测其对槲皮素的增溶作用。结果:羧甲基-β-环糊精溶血作用小;对槲皮素的增溶作用显著。结论:羧甲基-β-环糊精可在药物制剂中作为一种新辅料广泛应用。Objective: To study the hemolysis of carboxymethyl-β-cyclodextrin (CM-β-CD) in vitro and its effect on the solubilization of quercetin in water. Methods: The synthesized product was identified by IR spectrophotometry and 13C-NMR spectrometry, the hemolysis study was carried out by means of red blood cells isolated from whole human blood, and the effect of CM-β-CD on solubilization of quercetin in water was studied by UV spectrophotometry. Results: The hemolytic potential of CM-β-CD was very small and had a remarkable effect on solubilization of quercetin in water. Conclusion: CM-β-CD may be applied as a new auxiliary material in preparation of medication.

关 键 词：羧甲基-β-环糊精 溶血 槲皮素 

分 类 号：TQ464.1[化学工程—制药化工]