粉末直接压片法制备川芎嗪骨架片最佳工艺研究  

Study on optimization technique for preparation of tetramethylpyr azine phosphate sustained-release tablet

作　　者：吴雪钗[1] 于波涛[1] 曾仁杰[1] 王林[2] 

机构地区：[1]成都军区总医院药学部,四川成都610083 [2]贵阳医学院药学系,贵州贵阳550002

出　　处：《西南国防医药》2005年第1期31-33,共3页Medical Journal of National Defending Forces in Southwest China

摘　　要：　目的:研制持续释药12 h的磷酸川芎嗪骨架片。方法:根据预实验结果,采用正交设计进行处方设计和工艺优化,并用中国药典(2000年版)释放度测定方法测定骨架片的体外释放度。结果:直接压片可得到理想的片型,缓释片体外释药1 h释放度为25 0%左右,12 h在90. 0%以上。12 h内释药特性符合Higuchi方程。结论:粉末直接压片法工艺简单可行,骨架片体外释放效果良好。Objective: To prepare the tetramethylpyrazine ph osphate tablet that can release constantly for 12 hours. Methods: According to the preliminary experiments, the optimization prescription de sign and technique were obtained by orthogonal design. Based on the method in Ch inese Pharmacopoeia(2000), the release rates of the prepared sustained-release t ablets were tested in vitro. Results: An ideal tablet model was obtained by direct powder compression. The release rate in vitro was about 2 5% at 1 hour and more than 90% at 12 hours. The release characteristics during 1 2 hours were correspondent with Higuchi equation. Conclusion: The technique of direct powder compression is simple and useful, and the prep ared sustained-release tablets release well during 12 hours in vitro.

关 键 词：法制 直接 根据 目的 持续 理想 

分 类 号：D915[政治法律—诉讼法学]