己酸孕酮、三苯氧胺及氨基导眠能对子宫内膜癌作用的研究  

Role of hydroxyprogesterone caproate, tamoxifen and aminoglutethemide in endometrial careinoma.

作　　者：陆惠娟[1] 杜心谷[1] 张惜阴[1] 

机构地区：[1]上海医科大学妇产科医院

出　　处：《现代妇产科进展》1994年第3期203-207,共5页Progress in Obstetrics and Gynecology

摘　　要：将子宫内膜癌７４例，分为７组单独或联合应用己酸孕酮，三苯氧胺和氨基导眠能治疗，光镜观察用药前后子宫内膜癌的形态学改变。结果：上述药物均能不同程度地抑制癌细胞生长，促其向成熟转化或发生退变，其中以三苯氧胺的作用尤为明显。癌细胞对上述药物的反应程度与癌分型、核分级有关，腺鳞癌、透明细胞癌和浆液乳头型腺癌反应不明显，而内膜型腺癌反应明显，两者的反应率有高度显著性差异（Ｘ２＝２０．８６Ｐ＜０．０１），粘液型腺癌反应介于两者之间。癌对药物反应程度随核分级增加而下降。Seventy-four patients With endometrial carcinoma were divided into seven groups and treated with hydroxyprogesterone caproate,tamoxifen (TAM) and aminoglutethemide (AG) separately or combinedly for 10￣14 days.The morphological changes were observed microscopically before and after the treatment. The findings showed that there were various degrees of inhibition on growth of carcinoma cells with the appearance of maturative changes. Analys is of the initial effect suggested that TAM seemed to be most effective, but these intergroup differences were not statistically significant. Furthermore,responses of carcinoma cells to these inedicines were associated with their histologic type and nuclear grade. The clinical use of these medicines was discussed.

关 键 词：子宫内膜癌 己酸孕酮 三苯氧胺 

分 类 号：R737.330.5[医药卫生—肿瘤]