翼状胬肉组织中Bcl-2和ICAM-1的表达  

Expression of Bcl-2 and ICAM-1 in pterygium

作　　者：黄伟奇[1] 杨锦荣[2] 姚运红[2] 朱朝花[1] 刘凌[1] 

机构地区：[1]广东医学院附属医院眼科,中国广东省湛江市524001 [2]广东医学院病理学教研室,中国广东省湛江市524001

出　　处：《国际眼科杂志》2005年第1期86-88,共3页International Eye Science

基　　金：2003年中国湛江市科技攻关项目~~

摘　　要：目的:研究翼状胬肉组织中Bcl-2和细胞间粘附分子–1(ICAM-1)的表达,以及Bcl-2和ICAM-1表达间的关系。方法:应用免疫组织化学法检测30例翼状胬肉组织中Bcl-2和ICAM-1的表达,并与正常结膜组织进行比较。结果:翼状胬肉组织中Bcl-2和ICAM-1的表达均明显高于正常结膜组织(χ2=5.92和χ2=6.65,P<0.01);翼状胬肉的临床分型与Bcl-2和ICAM-1的阳性表达有关﹙P<0.05﹚;翼状胬肉组织中Bcl-2和ICAM-1阳性表达间存在非常显著正相关﹙r=0.628,P<0.01﹚。结论:翼状胬肉组织中Bcl-2和ICAM-1的表达增加,在翼状胬肉的发生和发展中可能通过调控细胞增殖和细胞凋亡起着重要的作用。ATM: To study the expression and the relationship of Bcl-2 and intercellular adhesion molecule-1 (ICAM-1) in pterygium.· METHODS: The expression of Bcl-2 and ICAM-1 were detected in 30 cases with pterygium by immunohistochemical method and were compared with the normal conjunctiva epithelium in other 10 cases.· RESULTS: The expression of Bcl-2 and ICAM-1 was significantly higher in pterygium than in normal conjunctiva epithelium (P <0.01). The expression of Bcl-2 and ICAM-1 did correlate with the clinical type in pterygium. The expression of Bcl-2 was significantly related to that of ICAM-1.· CONCLUSION: The increase of Bcl-2 and ICAM-1 are presented in pterygium, which may contribute to the progression through cell proliferation and apoptosis.·

关 键 词：翼状胬肉 ICAM-1 BCL-2 阳性表达 正常 结膜 BEL-2 结论 目的 正相关 

分 类 号：R777.33[医药卫生—眼科]