海德堡视网膜断层扫描仪测量黄斑厚度的可重复性研究  

Reproducibility of Heidelberg retinal tomograph measuring the macular retinal thickness

作　　者：梁远波 [1] 徐亮 [1] 余秋蓉 [2] 陈建华 [1] 朱思泉 [1] 郭淑珍 [1] 

机构地区：[1]100730,首都医科大学附属北京同仁医院眼科中心 [2]中山大学中山眼科中心

出　　处：《中华眼底病杂志》2005年第2期103-105,共3页Chinese Journal of Ocular Fundus Diseases

摘　　要：目的　对海德堡视网膜断层扫描仪 (HRT)黄斑水肿分析软件 (MEM)进行黄斑厚度测量的可重复性评价。　方法　对 6 2名正常人 (9～ 6 8岁 )用 HRT- 黄斑程序进行检查 ,对黄斑部视网膜信号宽度、中心凹视网膜信号宽度和黄斑水肿指数进行均数分析、t检验和相关分析 ,对个体内重复测量的变异性采用变异系数、95 %耐受限 (TC)、类内相关系数 (ICC)进行研究。　结果　正常人的黄斑部视网膜信号宽度为 (0 .734± 0 .2 36 ) mm,中心凹视网膜信号宽度为 (0 .781± 0 .2 4 3) mm,平均水肿指数 E=(1.16 9±0 .6 19)。各参数的重复测量变异系数分别为 :视网膜信号宽度 (8.7± 6 .8) % ,中心凹视网膜信号宽度(8.5± 6 .7) % ,平均水肿指数 (15 .6± 13.9) % ;个体内连续重复测量发生改变的 95 % TC分别为 ,视网膜信号宽度 0 .131(8.9% ) ;中心凹信号宽度 0 .137(10 .5 % ) ;平均水肿指数 0 .198(7.4 % )。同一操作者对同一个体进行多次重复测量的 ICC分别为 :黄斑区视网膜信号宽度 0 .95 0 ;中心凹信号宽度 0 .94 9;平均水肿指数 0 .898。　结论　海德堡视网膜断层扫描仪 MEM软件 ,具有无创、快速、可重复性较好等特点 ,为视网膜厚度相关的黄斑疾病的客观定量监测提供了一种新的手段。Objectives To evaluate the reproducibility of Heidelberg retina tomograph (HRT) macular edema module(MEM) measuring the macular retinal thickness. Methods Sixty-two healthy volunteers (9-68 years old) were examined by HRT-II procedure. The retinal signal width (SW) at macula and fovea and macular edema index (E) were recorded for t-test, Pearson linear-correlation analysis. Intra-subject variation repeatedly measured was analyzed with coefficient of variation, 95% tolerance limits of change (TC), and intra-class coefficient of correlation (ICC). Results In healthy individuals, retinal SW was (0 734±0 236) mm at macula,and (0.781±0.243) mm at fovea; macular E was (1.169±0 619). The coefficient of variation repeatedly measured: retinal SW was (8.7±6 8)%,retinal SW at the fovea was (8.5±6.7)%, and the average was (15.6±13 9)%; 95%TC of intra-subject sequential repeated measurement was 0.131 (8.9%) of retinal SW, 0 137 (10.5%)of fovea SW,and 0 198 (7.4%) of average E. ICC of one individual repeatedly measured by one operator was 0 950 of macular SW, 0.949 of fovea SW, and 0.898 of average edema index. Conclusions HRT-II MEM is noninvasive, fast and highly reproducible, which provides a new technique to monitor the objective quantification of macular diseases related to retinal thickness.

关 键 词：海德堡视网膜断层扫描仪 中心凹 水肿 黄斑 重复测量 可重复性研究 正常人 指数 结论 个体 

分 类 号：R774.5[医药卫生—眼科]