乳腺癌survivin和TK1的表达及其与腋窝淋巴结转移的关系  

Expression of surviving and its correlation with thymidine kinase and axillary lymph node metastasis in breast cancer

作　　者：高庆[1] 吴建平[2] 毛永荣[2] 兰海[3] 

机构地区：[1]湖北省黄梅县人民医院肿瘤科,435500 [2]湖北省肿瘤医院病理科,武汉430079 [3]武汉大学中南医院肿瘤科,湖北430071

出　　处：《肿瘤研究与临床》2005年第1期10-12,共3页Cancer Research and Clinic

摘　　要：目的探讨乳腺癌survivin蛋白的表达及其与肿瘤细胞增生和腋窝淋巴结转移的关系。方法收集乳腺癌60例,其中有腋窝淋巴结转移的28例,用免疫组化染色检测survivin和胞质胸腺嘧啶核苷激酶(cytosolic thymidine kinase, TK1)蛋白的表达情况。结果①乳腺癌组织中有survivin蛋白的表达,其阳性表达率为64.9 %。②survivin蛋白表达阳性的乳腺癌细胞TK1的标记指数明显高于survivin蛋白表达阴性者。③无腋窝淋巴结转移的乳腺癌survivin蛋白阳性表达率明显低于有腋窝淋巴结转移者。结论乳腺癌组织中有survivin蛋白的表达,且其表达与肿瘤细胞增生和腋窝淋巴结转移有关。Objective To investigate the expression of survivin and its correlation with tumor thymidine kinase and axillary lymph node metastasis in breast cancer. Methods Expression of survivin and cytosolic thymidine kinase(TK) in 60 cases of breast cancer(28 cases with axillary lymphonode metastasis) were measured by immunohistochemistry. Results There was expression of survivin in breast cancer; labeling index(LI) of TK in breast cancer cells with positive expression of survivin was significantly higher than that with negative expression of survivin;the positive percent of survivin expression in breast cancer with axillary lymph node metastasis was higher than that without axillary lymph node metastasis. Conclusions The expression of survivin in breast cancer is related to TK and axillary lymph node metastasis.

关 键 词：SURVIVIN 胸腺嘧啶核苷激酶 乳腺肿瘤 转移 

分 类 号：R737.9[医药卫生—肿瘤] R730.43[医药卫生—临床医学]