OX-LDL和PON-1与老年动脉粥样硬化性脑梗死的关系  

Relationship between Oxidized Low Density Lipoprotein Paraoxonase-1 and Senile Arteriosclerotic Thrombotic Cerebral Infarction

作　　者：王彤宇[1] 田桂玲[2] 程焱[2] 梁浩[2] 

机构地区：[1]天津市渤海石油医院神经内科,300452 [2]天津医科大学总医院神经内科

出　　处：《天津医药》2005年第3期151-154,共4页Tianjin Medical Journal

摘　　要：目的:研究氧化低密度脂蛋白(OX-LDL)水平和对氧磷酯酶-1(PON-1)活性对动脉粥样硬化性血栓性脑梗死(ATCI)的致病和保护意义。方法:对146例ATCI患者(ATCI组)应用ELISA双抗体夹心法测定血清OX-LDL水平,紫外分光光度法测定血清PON-1活性,同时测定其他血脂项目和血糖水平,并与105例健康体检者(对照组)比较。结果:ATCI组血清OX-LDL水平高于对照组(P<0.01),PON-1活性低于对照组(P<0.01),且ATCI组血清OX-LDL水平与TG、脂蛋白a犤Lp(a)犦、PON-1活性水平、年龄相关,且与梗死面积、部位有关;其PON-1活性亦与OX-LDL水平、年龄相关,且与梗死面积、部位有关。结论:血清OX-LDL水平的升高和PON-1活性的下降与ATCI有关,对此两者水平的监测和早期干预可能有助于预防ATCI的发生。Objective To study the changes of serum OX-LDL level and the activity of PON-1 in arteriosclerotic thrombotic cerebral infarction ATCI individuals and learn their effects on ATCI. Methods The levels of serum OX-LDL and PON-1 activity were observed in 146 ATCI patients and 105 control individuals meanwhile blood lipid and FBG were also observed. Results The level of serum OX-LDL in ATCI was higher than that of control group P < 0.01 and the activity of PON-1 in ATCI was lower than that of control group P < 0.01. The serum OX-LDL level had correlations with TG Lap PON-1 age infarction area and infarction site. The activity of PON-1 had correlations with OX-LDL age infarction area and infarction site. Conclusion The rise of serum OX-LDL and the reduction of PON-1 activity might accelerate the processes of arteriosclerosis and ATCI. It is suggested that the control of levels of OX-LDL and PON-1 may prevent ATCI.

关 键 词：OX-LDL 血清 对照组 动脉粥样硬化性脑梗死 活性 老年 梗死面积 水平 结论 目的 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R541.4[医药卫生—临床医学]