重症肌无力患者临床绝对评分和电生理检查的相关性研究  

Study on the Correlation between Clinical Absolute Scores and Electrophysiological Results in Myasthenia Gravis

作　　者：刘银红[1] 许贤豪[2] 侯世芳[2] 高平[2] 秦绍森[2] 王湘[2] 燕明宗 

机构地区：[1]中国协和医科大学,北京100730 [2]卫生部北京医院神经内科,北京100730 [3]山东省蓬莱市中医院神经内科,山东蓬莱265600

出　　处：《中国神经免疫学和神经病学杂志》2005年第2期67-69,共3页Chinese Journal of Neuroimmunology and Neurology

摘　　要：目的研究重症肌无力(MG)患者临床绝对评分和电生理检查结果的相关性。方法61例MG患者在进行临床绝对评分之后依次进行桡、腋、副和面神经低频重复电刺激(RNS)和伸指总肌单纤维肌电图(SFEMG)检查。通过SPSS100软件分析临床绝对评分与RNS和SFEMG结果的相关性。结果临床绝对评分与桡、腋、副和面神经低频RNS的波幅衰减程度之间均呈显著正相关;临床绝对评分与SFEMG结果中的平均jitter值、异常电位对比例和阻滞电位对比例之间呈非常显著正相关,而与正常电位对比例之间呈非常显著负相关。结论临床绝对评分的高低与电生理的检查结果间有很好的一致性,能够比较准确、客观地反映MG病情的严重程度。Objective To investigate the correlation between clinical absolute scores and electrophysiological parameters in patients with myasthenia gravis (MG). Methods The clinical absolute scores, repetitive nerve stimulation (RNS) of radial, axillary, accessory and facial nerves at low rates, and single fiber electromyography (SFEMG) on extensor digitorum communis were performed in turns on 61 patients with MG. These results were statistically analyzed by SPSS10.0 software. Results The clinical absolute score is correlated well with the ~degrees of amplitude decrement of RNS of each one in the 4 nerves at low rates; it is positively correlated with mean jitter value, the percentage of increased potential pairs and the percentage of blocking potential pairs respectively and negatively with the percentage of normal potential pairs. Conclusions The clinical absolute score is correlated well with the electrophysiological parameters and can accurately and objectively reflect the severity and fatigability of muscular weakness in patients with MG.

关 键 词：重症肌无力 临床绝对评分 重复电刺激 单纤维肌电图 

分 类 号：R746.1[医药卫生—神经病学与精神病学]