康复训练对急性脑梗死大鼠行为学及体感诱发电位的影响  

Effects of rehabilitation training on behavior and sensory evoked potential of rats with acute cerebral infarction

作　　者：秦颖[1] 唐强[2] 倪金霞[2] 朱文增[2] 段淑荣[1] 王德生[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院,黑龙江哈尔滨市150001 [2]黑龙江中医药大学附属第二医院康复科,黑龙江哈尔滨市150001

出　　处：《中国康复理论与实践》2004年第12期729-730,共2页Chinese Journal of Rehabilitation Theory and Practice

基　　金：中国博士后基金课题 (No.中博基 [2 0 0 0 ] 2 3号 ) ;黑龙江省自然科学基金项目 (No .D0 1 2 5) ;哈尔滨市科委攻关计划项目(No .0 1 1 4 2 1 1 1 35 6)。

摘　　要：目的观察康复训练对急性脑梗死大鼠脑功能恢复及体感诱发电位潜伏期的影响。方法将 3 0只大鼠随机分为假手术组 (A组 )、造模组 (B组 )和康复组 (C组 ) ,采用血管内栓线法制备脑缺血动物模型 ,术后 2 4h、3d、7d分别进行Bederson神经功能评分、平衡木、转棒、网屏测评及体感诱发电位 (SEP)潜伏期测定。结果B、C组大鼠的Bederson评分各时间点均与A组有非常显著性差异 (P <0 .0 1) ,随时间延长 ,A组大鼠的各项指标很快恢复 ,与B、C组有非常显著性差异 (P <0 .0 1) ;C组大鼠的平衡木评分在术后 3d与B组有显著性差异 (P <0 .0 5 ) ,术后 7d ,除Bederson评分外 ,C组大鼠的各项指标与B组有显著性差异(P <0 .0 1或P <0 .0 5 ) ;B、C组大鼠术后即刻SEP潜伏期与A组有非常显著性差异 (P <0 .0 1) ,术后 7d ,C组大鼠SEP潜伏期的改善程度与术后即刻相比亦有非常显著性差异 (P <0 .0 1)。结论康复训练能提高脑梗死大鼠的平衡、行走及抓握能力 ,并能通过调整脑梗死大鼠皮层SEP潜伏期使缺血损伤的脑细胞恢复功能。ObjectiveTo observe effects of rehabilitation training on behavior and sensory evoked potential of rats with acute cerebral infarction.Methods30 male Wistar rats were randomly divided into sham operation groups (group A), model group (group B), and rehabilitation group (group C). Animal model was made by blocking the middle cerebral artery (MCA). For each group, the Bederson Neural Function was scored and balancing wood, rotating bar, and net screen were tested at the 24 hours, 3rd day and 7th day after operation respectively. The sensory evoked potential (SEP) latency of each group was also tested right after operation and on the 7th day after operation.ResultsComparing with group A, Bederson Neural Function scores of groups B and C indicated significant differences at each time ( P<0.01). The ability of grasping, walking and coordinating of all groups handicapped 24 hours after operation, however, with time continuing, every function of group A restored and that of group B or C improved partly, but showed significant difference compared with group A ( P<0.01). On the 3rd day after operation, balancing wood test of group C was better than that of group B ( P<0.05), on the 7th day after operation, except Bederson Neural Function scores, there were significant difference between groups C and B ( P<0.01 or P<0.05). Right after operation, compared with group A, the SEP latency of group B and C showed significant difference ( P<0.01), on the 7th day after operation, the SEP latency of group C improved significantly compared with itself right after operation ( P<0.01).ConclusionThe rehabilitation training can improve the MCAO rats' ability of equilibrating, grasping and walking and adjust the abnormal latency of SEP after MCAO, and prevent the nerve cells from damage caused by ischemic trauma. [

关 键 词：脑梗死 康复 大脑中动脉闭塞(MCAO) 体感诱发电位(SEP) 

分 类 号：R743.3[医药卫生—神经病学与精神病学]