乳腺癌放、化疗致放射性肺炎与相关因素分析  

Correlation factor analysis between radiation pneumonities and chemoradiotherapy in breast cancer patients

作　　者：李惠平[1] 王俊杰[1] 马力文[1] 张淑兰[1] 邓惠静[1] 贾廷珍[1] 

机构地区：[1]北京大学第三医院肿瘤治疗中心肿瘤化疗放射病科,100083

出　　处：《中华放射医学与防护杂志》2004年第6期507-509,共3页Chinese Journal of Radiological Medicine and Protection

摘　　要：目的　观察乳腺癌放疗的患者使用化疗药物及其他因素与放射性肺炎发生率的关系。方法　采用回顾性 85例术后辅助放、化疗的乳腺癌患者放疗的照射剂量 ,使用化疗药物的时间、种类、患者的年龄和肺部疾病与放射性肺炎发生率的关系。结果　临床有放射性肺炎症状者 5例 ,其中 1例需要积极治疗 ;有影像学改变的放射性肺炎共 16例 ,为 18 8% ,与放疗剂量、化疗时间、药物种类和肺部疾病史有关。结论　照射剂量、放疗后化疗、肺部原有疾病增加了放射性肺炎的发生率。Objective To investigate the relationship between radiotherapyinduced lung injury and chemotherapy agents as well as other factors. Methods A total of 85 breast cancer patients received radiotherapy with sequential or concurrent chemotherapy after surgery were analysed for radiation dose,chemotherapy schedule, age,and lung disease history. Results Five patients had clinical symptoms of radiation pneumonitis,one of them was necessary to treat and 16 patients developed radiological changes (18.8%).Close relationship was noted between incidence of radiation pneumonitis and radiation dose,timing and drugs used in chemotherapy and lung disease history. Conclusion High irradiation dose,concurrent chemotherapy,and lung disease history can increase the rate of radiotherapyinduced pulmonary injury in breast cancer patients.;

关 键 词：放射性肺炎 化疗 乳腺癌 患者 发生率 放疗 相关因素分析 治疗 药物种类 症状 

分 类 号：R737.9[医药卫生—肿瘤] R818.841[医药卫生—临床医学]