小剂量多巴胺对严重烫伤大鼠血清乳酸、一氧化氮水平的影响  

Effects of small dose dopamine on serum lactic acid and serum nitric oxide in severely scalded rats

作　　者：潘文东[1] 周明[1] 杨正文[1] 李木惠[1] 张道全[1] 

机构地区：[1]解放军第59中心医院,云南开远661000

出　　处：《西南国防医药》2004年第1期6-8,共3页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的 :观察小剂量多巴胺对严重烫伤大鼠血清乳酸和一氧化氮的影响。方法 :大鼠预置心导管 ,3 0 %Ⅲ度烫伤后静脉复苏 ,观察小剂量多巴胺 (3 μg/kg min)持续给药后大鼠的血清乳酸、一氧化氮水平的变化。 结果 :与对照组相比 ,小剂量多巴胺治疗能显著降低严重烫伤大鼠血清中的乳酸、一氧化氮水平 ,以伤后 3～ 12h明显。结论 :小剂量多巴胺可降低严重烫伤大鼠休克期血清乳酸。Objective: To observe the effects of small dose dopa mine on serum lactic acid and serum nitric oxide in severely scalded rats. Methods: The rats with 30% of the total body surface area (TBSA) scalded were placed cardiac catheters and intravenously injected with small dos e dopamine (3ug/kg/min). We measured the changes of serum lactic acid and nitric oxide. Results: Compared with control group, the lactic acid an d nitric oxide content of the rats in dopamine group were significant lower. Conclusion: Small dose dopamine can decrease the lactic acid and n itric oxide content in severely scalded rats.

关 键 词：用药剂量 多巴胺 烫伤 大鼠 血清 乳酸 一氧化氮 休克期 

分 类 号：R644[医药卫生—外科学] R982[医药卫生—临床医学]