大鼠原位肝移植动物模型的建立  

The establishment of orthotopic liver transplantation in rat

作　　者：路明[1] 苗玉清[1] 张金辉[1] 赵晋明[1] 买买提江.阿不都卡得尔 温浩[1] 

机构地区：[1]新疆医科大学第一附属医院普外科

出　　处：《新疆医科大学学报》2005年第2期145-147,共3页Journal of Xinjiang Medical University

摘　　要：目的:建立稳定的大鼠原位肝移植模型,为移植免疫学研究提供动物实验技术平台. 方法:采用远交系Wistar和远交系SD大鼠,用二袖套一吻合法(门静脉和肝下下腔静脉行袖套法,肝上下腔静脉行吻合法)建立大鼠原位肝移植模型. 结果:共行大鼠原位肝移植30例次,其中Wistar-Wistar大鼠移植20例次,大鼠6～7 d死亡,平均生存5.1 d.SD-Wistar大鼠移植10例次,大鼠4～5 d死亡,平均生存3.8 d. 结论:二袖套一吻合法操作简便,手术成功率高,可作为肝移植试验的有效方法.Objective: To make an ideal model for liver transplantation. Methods: Two Cuff (portal vein and infrahepatic vena cava) technique was applied in the production of this animal model in Wistar rats and SD rats. Results: With the modifiation, a successful rate of 83.3% was achieved in the production of the experimental model with anhepatic period of on average 19 minutes. Conclusion: The results show that the model is easily available and highly reproducible and can be used in the experiment of liver transplantation.

关 键 词：肝 移植 大鼠 袖套法 

分 类 号：R-332[医药卫生] R657.3