广谱抗菌剂普卢利沙星的合成  

Synthesis of Broad-spectrum Antimicrobial Prulifloxacin

作　　者：唐兆成 金义翠[2] 

机构地区：[1]江苏正大天晴药业有限公司,江苏连云港222006 [2]连云港职业技术学院化工系,江苏连云港222006

出　　处：《精细与专用化学品》2005年第5期16-18,共3页Fine and Specialty Chemicals

摘　　要：以 3, 4- 二氟苯胺为起始原料,经过加成、硫代缩环、环合、缩合等一系列反应,最后得产品普卢利沙星;经过元素分析,产品的元素组成为C21H20FN3O6S,精制品与对照品的EA、UV、IR、NMR、MS、DSC、TG和X -ray测定结果一致,两者为同一结构、同一晶型化合物;产品的纯度达到 99. 0%以上,改进后的工艺更适合工业化生产。Using 3,4-difluoroaniline as raw material, prulifloxacin with purity of 99.0% was synthesized through a range of reactions namely addition, thionation, cyclization and condensation reactions. Its composition was confirmed as C 21H 20FN 3O 6S by the elemental analysis. The refined product is identical with the standard sample in the characterization results of EA、UV、IR、NMR、MS、DSC、TG and X-ray, it indicated that they have the same structure and crystal form. The improved technology is much suitable for commercial production.

关 键 词：环合 起始原料 氟苯 合成 缩合 广谱抗菌 精制 普卢利沙星 对照品 FN 

分 类 号：TQ463[化学工程—制药化工] R978.1[医药卫生—药品]