原发性中枢神经系统淋巴瘤的临床病理及与EB病毒的关系  

Clinicopathologic changes and Eptein-Barr virus in situ hybridization of primary central nervous system lymphoma

作　　者：杜俊[1] 王征[1] 杨丽[1] 孙肇武[1] 刘冬戈[1] 

机构地区：[1]北京医院病理科,北京100730

出　　处：《诊断病理学杂志》2005年第1期37-40,i011,共5页Chinese Journal of Diagnostic Pathology

摘　　要：目的　探讨原发性中枢神经系统淋巴瘤 (primarycentralnervoussystemlymphoma ,PCNSL)的临床病理特点及与EB病毒 (EBV)的关系。方法　对 6例PCNSL进行临床病理观察 ,采用ABC法行LCA、CD2 0、CD79a、CD4 5RO、CD3免疫组化标记 ,并以生物素标记的EBER 1寡核苷酸为探针进行原位杂交检测。结果　 6例均无HIV感染病史 ,其中 5例为B细胞来源淋巴瘤 ,1例为T细胞来源淋巴瘤 ,EB病毒原位杂交检测均为 (- )。结论　PCNSL多数为B细胞性淋巴瘤 ,少数为T细胞性淋巴瘤 ,非HIV感染的PCNSL的发生可能与EB病毒感染关系不密切。Objective To study the clinicopathologic features of primary central nervous system lymphoma (PCNSL) and the relationship between P CNSL and Eptein-Barr virus (EBV) infection. Methods We collec ted 6 speci ments of PCNSL from our Department of Pathology during 1992—2003. Clinicopathol ogic examination and immunohistochemical stain for LCA,CD20,CD79a,CD45RO and CD3 wer e performed with ABC mothod,and EBER-1 oligo-nuceotide probes labeled by bioti n in situ hybridization was used for detection of EBV. Results None of t he 6 cases were HIV positive patients; five of the 6 PCNSL were of B lymphocyte o rigin, one of the 6 PCNSL was of T lymphocyte origin; and all of the 6 specim ents showed negative signal in EBEV-1 in situ hybridization. Conclusion The majority of PCNSL are B-cell lymphoma and minority of PCNSL are T-cell lymphoma. The role of EBV in non-HIV infected PCNSL may be not import ant.

关 键 词：原发性中枢神经系统淋巴瘤 EPSTEIN-BARR病毒 原位杂交 病理学诊断 B细胞性淋巴瘤 

分 类 号：R739.4[医药卫生—肿瘤] R511[医药卫生—临床医学]