拓僖联合化疗方案治疗晚期胃癌的临床分析  

Clinical efficacy of LFPH in treatment of advanced gastric cancer

作　　者：杨家梅[1] 韩娜[1] 梁冰[1] 

机构地区：[1]郑州大学第二附属医院肿瘤科,郑州450003

出　　处：《中国肿瘤临床与康复》2005年第1期69-71,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨拓僖(HCPT)联合氟尿嘧啶(5Fu)/亚叶酸钙(LV)及顺铂(DDP)的LFPH方案治疗晚期胃癌的疗效及毒副反应。方法将64例随机分为治疗组及对照组,治疗组采用LFPH方案,具体用药方案为:HCPT每天6～8mg/m2,静脉滴注,第1～5天;LV每天100～200mg,静脉滴注2h,第1～5天;5Fu每天425mg/m2,静脉滴注3h,第1～5天;DDP30mg/m2,第1～3天静脉滴注。对照组采用LFAP方案,即阿霉素(ADM)联合5Fu/LV及DDP,具体用药:ADM40mg/m2,分1～2d静脉冲入;5Fu、LV及DDP的用法和用量同治疗组。结果治疗组的有效率分别为29.0%和33.3%,差异无显著性。治疗组的骨髓抑制、脱发和消化道反应中的恶心、呕吐等副反应发生率低于对照组;治疗组生活质量改善情况优于对照组,两组差异有显著性。结论HCPT联合5Fu/LV及DDP的方案治疗晚期胃癌有一定的疗效,临床受益反应较高,生活质量改善较明显,毒副反应较低。Objective To investigate the antitumor efficacy of LFPH which is composed of HCPT,5-Fu,LV and DDP and its side effects.Methods 64 cases were divided into study group and control group.All patients received LV 100～200 mg/d by intravenous infusion (IV) in 2 hours for 5 days,5-Fu 425 mg/(m^2·d),iv,in 3 h for 5 consecutive days and DDP 30 mg/m^2,iv,for 3 days.Patients in study group also received HCPT 6-8 mg/(m^2·d),iv,for 5 consecutive days,while patients in control group received ADM 40 mg/m^2,iv in 1-2 days.Result The response rates of the two groups were 29.0% and 33.3% and there was no significant difference between the two groups.The incidences of bone marrow inhibition, alopecia, nausea and vomiting in study group were significantly lower than in control group and quality of life in study group was significantly better than that in control group. Conclusion LFPH is an effective and tolerable regimen for gastric cancer.

关 键 词：胃肿瘤/化学疗法 拓僖 

分 类 号：R735.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]