艾灸对实验性类风湿关节炎滑膜细胞原癌基因c-fos和c-myc mRNA表达的影响  

Effects of moxibustion on the expression of protooncogene c-fos and c-myc mRNA in experimental arthritis

作　　者：余俊辉[1] 刘旭光[2] 余曙光[2] 蔡美英[1] 周昌华[1] 赵宗蓉[1] 张平[1] 

机构地区：[1]四川大学华西基础与法医学院免疫教研室,四川成都610041 [2]成都中医药大学针灸推拿学院

出　　处：《西部医学》2005年第2期108-110,共3页Medical Journal of West China

基　　金：国家自然科学基金重大研究计划资助项目 (NO:90 2 0 90 2 2 )

摘　　要：目的　观察艾灸对实验性类风湿关节炎滑膜细胞原癌基因 c- fos、c- myc m RNA表达的影响 ,初步探讨艾灸对 RA滑膜细胞内分子信号传导的调控。方法　在日本大耳白兔右后足踝关节部皮内注射福氏完全佐剂造模 ,经过艾灸治疗 ,通过半定量 RT- PCR测定 c- fos和 c- myc m RNA的表达量。结果　治疗组 c- fos和 c- myc m RNA表达量显著低于造模组 (P<0 .0 1 )。结论　艾灸治疗能够降低 c- fos和 c- myc m RNA的表达 ,影响生长因子信号传导系统。Objective To investigate the role of moxibustion in rheumatoid arthritis(RA) by detecting the expression of protooncogene c-fos and c-myc mRNA in experimental arthritis rabbits. Methods The experimental rabbit model was set up by injection of complete adjuvant into right ankle joint. Rabbits were grouped randomly into three groups: normal, model and moxibustion-treatment groups. The expression of c-fos and c-myc mRNA was detected by semi-quantity RT-PCR. Results Compared with model group, the expression of c-fos and c-myc mRNA was significantly reduced in moxibustion-treatment group(P<0.01).Conclusion Moxibustion may play a protective role in RA by downregulating the expression of protooncogene c-fos and c-myc.

关 键 词：实验性类风湿性关节炎 c—fos c—myc 滑膜细胞 艾灸 

分 类 号：R730.5[医药卫生—肿瘤] R738.2[医药卫生—临床医学]