尼美舒利对大鼠慢性脑缺血损害的保护作用  

Neuroprotective effect of nimesulide on brain after chronic cerebral hypoperfusion in rats

作　　者：孙治坤[1] 刘其强[1] 王宪远[2] 王焕荣[1] 朱永林[1] 

机构地区：[1]郑州大学第二附属医院神经内科,郑州450014 [2]郑州大学第二附属医院病理科,郑州450014

出　　处：《实用神经疾病杂志》2005年第2期34-36,共3页

摘　　要：目的　探讨诱导型环氧和酶 (COX -2 )抑制剂尼美舒利对慢性脑缺血损害的保护作用。方法　大鼠随机分为对照组、缺血组和治疗组 ,治疗组于术后 2 4h开始以尼美舒利 (6mg/kg)每日灌胃 ,连续 60d ,各组于 60d后做病理染色、GFAP免疫组化染色及脑组织内MDA和SOD含量的测定。结果　与对照组相比 ,缺血组GFAP阳性细胞明显增多 ;脑内的SOD含量下降 ,MDA含量增多。治疗组以上变化明显减轻 ,且有显著性差异。结论　COX -2抑制剂尼美舒利对慢性脑缺血损伤有脑保护作用。Objective To investigate the neuroprotective effect of a cyclooxygenase-2 inhibitor nimesulide on brain damages after chronic cerebral hypoperfusion. Methds 48 SD rats were distributed into sham operation group, and nimesulide group randomly. The nimesulide group received a daily oral dose of 6mg/kg nimesulide from 24h after the operation to 60 days. Then observe the activation of astrocytes and MDA contents and SOD activities in brain tissues. Results There were obvious proliferation of astrocytes ,elevation of MDA and reduction of SOD in hypoperfusion group. In nimesulide group all the changes were reduced significantly. Conclusion The results confirms the ability of nimesulide to reduce chronic cerebral hypoperfusion brain damage.

关 键 词：尼美舒利 慢性脑缺血 治疗组 保护作用 大鼠 对照组 GFAP SOD 损害 含量 

分 类 号：R743[医药卫生—神经病学与精神病学] R971.1[医药卫生—临床医学]