非小细胞肺癌p53蛋白表达量及倍体测定与预后关系  

The Relationship between the Expression and Ploidy of p53 and Prognosis in Non-small Cell Lung Cancer

作　　者：谢成耀[1] 苏禄晖[2] 刘楠[1] 李庆昌[1] 李宗铉[1] 王恩华[1] 

机构地区：[1]中国医科大学病理教研室,辽宁沈阳110001 [2]沈阳医学院病理生理教研室

出　　处：《解剖科学进展》2005年第1期25-26,共2页Progress of Anatomical Sciences

基　　金：教育部留学回国人员科研基金(2002-247)

摘　　要：目的　通过非小细胞肺癌p53蛋白表达量及倍体测定,结合临床病理学特点,探讨患者预后的影响 因素。方法　应用流式细胞术检测120例非小细胞肺癌的p53蛋白表达量及DNA倍体。结果　淋巴结转移组 p53蛋白表达量高于无转移组,COX单因素分析表明,p53蛋白表达量、倍体及临床TNM分期均与预后有关,COX 多因素分析发现,仅p53蛋白表达量是独立的预后因素。结论　p53蛋白高表达可能是非小细胞肺癌患者预后不 良的主要因素之一。Objective To study the expression and ploidy of p53 in non-small cell lung cancer (NSCLC) and the relationship between p53 protein and prognosis. Methods The expressive level and ploidy of p53 in 120 NSCLC samples were detected by flow cytometry method. Result P53 protein expressed much more in NSCLC with lymph metastasis than in NSCLC without lymph metastasis. COX univariate analysis showed that the expression and ploidy of p53 and TNM classification were related to the prognosis of NSCLC patients. COX multivariate analysis indicated that the expressive level of p53 was the only independent prognostic factor. Conclusion The expression of p53 might be a primary prognostic factor of NSCLC patients.

关 键 词：P53蛋白表达 非小细胞肺癌 DNA倍体 预后不良 COX 患者 预后因素 结论 主要因素 特点 

分 类 号：Q786[生物学—分子生物学] R734[医药卫生—肿瘤]