血清胰岛素样生长因子Ⅰ水平与肝病关系的研究  

Study on the relationship of insulin-like growth factor-Ⅰ and liver disease

作　　者：刘宏景[1] 李沛[1] 刘惠敏[1] 刘宝根[1] 

机构地区：[1]杭州市第六人民医院检验科,浙江杭州310014

出　　处：《检验医学》2005年第2期95-97,共3页Laboratory Medicine

摘　　要：目的　探讨血清胰岛素样生长因子I(IGF Ⅰ)与不同程度肝病之间的关系。方法　应用酶联免疫吸 附试验(ELISA)检测73例慢性肝炎(CH)、57例肝硬化(LC)和30例慢性重型肝炎(CSH)患者及30名对照组血 清中IGF Ⅰ水平。并按Child pugh分级法将LC分为A(19例)、B(17例)、C(21例)3组。结果　CH、LC和CSH 患者的血清IGF Ⅰ分别为(199.0±40.8)ng/ml、(105.3±57.5)ng/ml和(48.9±33.2)ng/ml,均显著低于正常 对照[(275.09±98.99)ng/ml,P<0.001]。不同程度肝病患者血清中IGF Ⅰ水平差异有显著性,LC患者显著 低于CH患者(P<0.001),CSH患者显著低于LC患者(P<0.001);随肝功能Child pugh分级的增高,LC患者血 清IGF Ⅰ水平呈显著性递减趋势。结论　血清IGF Ⅰ水平与肝脏的病变程度有关。Objective To investigate the relationship between serum insulin-like growth factor-Ⅰ (IGF-Ⅰ) level and liver disease. Methods The serum IGF-Ⅰ levels in 73,57 and 30 patients with chronic hepatitis(CH), liver cirrhosis(LC) and chronic severe hepatitis(CSH) respectively, and 30 healthy controls were detected by enzyme linked immunosorbent assay (ELISA). LC patients were divided into three groups(group A, 19 patients; B, 17 patients and C, 21 patients) according to Child-pugh score. Results The serum IGF-Ⅰ levels in patients with CH, LC and CSH were( 199.0± 40.8) ng/ml,( 105.3± 57.5) ng/ml and ( 48.9± 33.2) ng/ml respectively, and decreased significantly compared with that in controls[( 275.09± 98.99) ng/ml, P< 0.001]. The serum IGF-Ⅰ levels in patients with different liver disease also were significantly different. IGF-Ⅰ level in CSH group was significantly lower than that in LC group (P< 0.001), and the latter was significantly lower than that in CH group(P< 0.001). As the Child-pugh score increased, the serum IGF-Ⅰ concentration was decreased significantly in LC patients. Conclusions The level of serum IGF-Ⅰ is related with the severity of liver disease.

关 键 词：胰岛素样生长因子Ⅰ 肝炎 肝功能 (ELISA 肝硬化 

分 类 号：R575.1[医药卫生—消化系统]