骨髓和血液学指标在判断慢性粒细胞白血病患者预后中的作用  

The prognostic value of bone marrow and blood examination variables in chronic myelocytic leukemia

作　　者：谭春艳[1] 覃桂芳[1] 曾维平[1] 王勇[1] 赵林[1] 

机构地区：[1]广西壮族自治区人民医院,广西南宁530021

出　　处：《检验医学》2005年第2期109-111,共3页Laboratory Medicine

摘　　要：目的　评估在传统治疗下影响慢性粒细胞白血病(CML)患者生存期的临床和实验室变量。方法　对 1980～2002年间的133例CML初诊患者的26个临床和实验室变量进行生存分析。结果　多变量Cox回归表 明,在传统治疗下,下列因素使患者存活时间较短:外周血白细胞总数>280×109/L(P=0.005)、血小板<120× 109/L或>650×109/L(P=0.003);骨髓涂片中无类戈谢细胞存在(P=0.008)、幼稚细胞(原始+早幼)比例 (负相关,P=0.0000)。结论　在传统治疗下,外周血白细胞(WBC)、血小板计数(BPC)、骨髓涂片类戈谢细胞、 幼稚细胞比例等4个实验室变量对CML患者的存活时间有显著影响。Objective To evaluate the predictive value of clinical and laboratory variables in chronic myelocytic leukemia(CML) treated by conventional chemotherapy. Methods 26 clinical and laboratory variables measured in 133 CML patients from 1980 to 2002 were included in the survival analysis. Results Multivariable analysis showed the following poor prognostic variables:White blood cell (WBC) count over 280×10 9/L in peripheral blood(P= 0.005),blood platelet count(BPC) less than 120×10 9/L or over 650×10 9/L in peripheral blood(P=0.003),greater percentage of bone marrow blasts (P=0.0000),and absence of bone marrow pseudo-Gaucher cells (P=0.008). Conclusions WBC count and BPC in peripheral blood,as well as pseudo-Gaucher and blast cells in bone marrow are significantly associated with survival time of CML patients by conventional chemotherapy.

关 键 词：慢性粒细胞白血病 生存分析 变量 存活时间 预后 

分 类 号：R733.72[医药卫生—肿瘤]