溃疡性结肠炎患者血浆和肠黏膜组织中神经降压素的含量及其临床意义  

Neurotensin Contents of Plasma and Intestinal Mucosal Tissues in Patients with Ulcerative Colitis and its Clinical Significance

作　　者：张惠芳[1] 张凤玉[2] 曹务成[3] 

机构地区：[1]新疆自治区人民医院消化科,830000 [2]新疆自治区人民医院胃镜室,830000 [3]新疆自治区人民医院核医学科,830000

出　　处：《胃肠病学》2005年第1期34-36,共3页Chinese Journal of Gastroenterology

摘　　要：背景:在新疆自治区,溃疡性结肠炎(UC)是一种常见病、多发病,其病因和发病机制至今尚不清楚,临床治疗效果亦不令人满意。目的:测定UC患者和对照者血浆和肠黏膜组织中神经降压素(NT)的含量,探讨NT含量与UC病因之间的关系。方法:采用放射免疫法测定31例UC患者(其中17例为少数民族)和38例对照者治疗前后血浆和肠黏膜组织中NT的含量。结果:UC患者血浆和肠黏膜组织中的NT含量较对照者显著降低(P<0.01);UC患者治疗后的血浆NT含量与治疗前相比无显著差异;少数民族UC患者的血浆NT含量与汉族患者相比无显著差异。结论:血浆和肠黏膜组织中NT含量降低可能与UC的发病有关。NT含量降低不是少数民族UC高发的直接原因。Ulcerative colitis (UC) is a commonly occurring disease in Xinjiang autonomous region, however, its etiopathogenesis has not been clarified, and the clinical therapeutic efficacy is still unsatisfactory. Aims: To detect the neurotensin ( NT) contents of plasma and intestinal mucosal tissues in patients with UC and in the controls, and to investigate the relevance of NT contents and etiopathogenesis of UC. Methods: The NT contents of plasma and intestinal mucosal tissues in 31 UC patients (including 17 minorities) and 38 controls were detected by radioimmunoassay before and after treatment. Results: The NT contents of plasma and intestinal mucosal tissues in UC patients decreased significantly as compared with those of the controls (P<0.01). In UC patients, there was no significant difference in the plasma NT content before and after treatment, so was the plasma NT contents between Han people and the minorities. Conclusions: The decreased plasma and intestinal mucosal NT contents may be correlated with etiopathogenesis of UC, but it is not the direct cause of high incidence of UC among the minorities.

关 键 词：溃疡性结肠炎 血浆 肠黏膜组织 神经降压素 含量 放射免疫测定 

分 类 号：R574.62[医药卫生—消化系统]