营养素合剂对模拟失重大鼠股骨的影响  

Effect of multiple micronutrients on femur of rats during simulated weightlessness

作　　者：黄纪明[1] 朱德兵[1] 李志霞[1] 李培荣[1] 洪建武[1] 白树民[1] 

机构地区：[1]航天医学工程研究所,北京100094

出　　处：《中国骨质疏松杂志》2005年第1期31-33,共3页Chinese Journal of Osteoporosis

摘　　要：目的　观察营养素合剂对抗模拟失重条件下大鼠骨丢失的效果 ,并初步探讨其机理。方法　SPF级SD大鼠 30只 ,随机平均分为 3组 :A组为自由活动对照组 ,大鼠自由活动 ;B组和C组为尾吊模拟失重组 ;A组和B组大鼠饲喂基础饲料 ;C组大鼠饲喂基础饲料添加 2 % (w/w)的营养素合剂 ,喂养 2 1d。结果　A组大鼠股骨的最大载荷、弹性载荷、最大应力、股骨密度、血清中骨钙素浓度、股骨钙量以及饲料钙的表观吸收率显著高于B组大鼠相应的指标 ;C组大鼠股骨的最大载荷、弹性载荷、最大应力、血清中骨钙素的浓度、左侧股骨钙量、对饲料钙的表观吸收率均显著性高于B组大鼠。结论　营养素合剂能明显提高模拟失重大鼠股骨质量。Objective To study the effect of multiple micronutrients on femur of rats during simulated weightlessness. Methods Thirty male SD rats were randomly divided into three groups: one free control group(group A) and two simulatied weightlessness groups(gropu B and C). Group A and C were fed with normal forages, and group C fed with normal forages supplemented with 2% (w/w) multiple micronutrients, and drank pure water ad libitum. Results The maximum load, elastic load, maximum stress, and calcium content of femur, serum BGP concentration, and apparent absorption of dietary calcium in group C were significantly higher than those in group B. Conclusions Multiple micronutrients stimulate the activity and production of osteocytes, and have a definite effect on reducing bone lose, as well as improve the physiological biomechanics in rats during simulated weightlessness.

关 键 词：大鼠 股骨 模拟失重 营养素 合剂 表观吸收率 骨钙素 血清 对照组 骨质量 

分 类 号：R852.22[医药卫生—航空、航天与航海医学] R681[医药卫生—临床医学]