妊娠肝内胆汁淤积症128例分析  

Clinical analysis of 128 cases with intrahepatic cholestasis in pregnancy

作　　者：周晔[1] 苏绮枫[1] 黄咏梅[1] 

机构地区：[1]中国福利会国际和平妇幼保健院,上海200030

出　　处：《上海医学》2005年第2期116-118,共3页Shanghai Medical Journal

摘　　要：目的探讨妊娠肝内胆汁淤积症(ICP)对母儿的影响及ICP分度的诊断意义.方法将2002年1月～2003年12月我院诊断的128例ICP患者(ICP组)与同期其他产妇(对照组,10 949名)进行比较,并将ICP组患者根据本院标准分为轻度和重度两个亚组进行分析.结果①ICP的发生率为1.16%,而双胎发生ICP的比率明显高于对照组.②ICP组分娩孕周、早产率、新生儿窒息发生率与对照组的差异有显著性(P<0.05).③轻度ICP亚组与重度ICP亚组在分娩孕周、丙氨酸转氨酶和羊水污染方面的差异有显著性(P<0.05).结论 ICP对胎儿的危害较大,对胎儿已成熟的ICP患者终止妊娠有助于改善围产儿的预后.Objective To appraise the risk of adverse pregnancy outcome resulting from intrahepatic cholestasis. Methods A retrospective study of 128 patients with ICP (ICP group) and 10 949 others (control group) who gave birth in our hospital were carried out from January 2002 to December 2003. The former was further subdivided into mild and severe subgroups. Results ①The incidence of ICP was 1.16%, it was found to be significantly higher in twin pregnancies. ②There were significant differences in new born asphyxia, preterm delivery and termination of the pregnancy between patients with ICP and the controls. ③105 cases were diagnosed as mild ICP and 23 severe ICP. There were significant differences in termination of the pregnancy, and elevation of serum ALT. The incidence of meconium contamination in amniotic fluid was higher in the severe ICP group. Conclusions Intrahepatic cholestasis has an adverse effect on fetal development which merits closer surveillance. When the fetus reaches maturity, delivery of the fetus can minimize the risk of adverse outcome.

关 键 词：ICP 对照组 患者 妊娠肝内胆汁淤积症 轻度 分娩孕周 重度 显著性 

分 类 号：R714.251[医药卫生—妇产科学]