老年帕金森病患者运动障碍的初步研究  

Preliminary study of motor impairment in Parkinson’s disease with elderly onset

作　　者：周国庆[1] 任苏虹[1] 段立晖[1] 汤兵[1] 李敏[1] 李华[1] 刘新峰[2] 祝华龙[3] 史兆荣[3] 

机构地区：[1]南京军区南京总医院干部神经内科,江苏南京210002 [2]南京军区南京总医院神经内科,江苏南京210002 [3]南京军区南京总医院保健科,江苏南京210002

出　　处：《医学研究生学报》2005年第3期221-223,共3页Journal of Medical Postgraduates

摘　　要：　目的: 探讨老年期发病的帕金森病 (PD)患者运动障碍的特点。　方法:按 1∶1配对病例对照研究的方法,选取诊断明确的老年及普通年龄发病的帕金森病患者各 44例,用国际通用的帕金森病统一评分量表 (UPDRS)第Ⅲ部分进行运动评分,用条件logistic回归分析老年期发病的PD患者运动障碍的特点。　结果:老年组患者运动迟缓(10. 6±4. 2)分、轴性损害症状(10. 7±3. 8)分及运动功能总评分为 (28. 8±7. 9)分,与对照组比较 (相应的各项评分分别为: 7. 8±3. 5, 8. 1±4. 3, 22. 9±6. 6)明显增高 (P<0. 01)。老年组患者合并对运动功能有影响的全身疾病的比例(21例,占 47. 7% )较对照组(9例,占 20. 4% )明显增多 (P<0. 01),但即使排除这些全身疾病的影响,老年发病的PD患者运动迟缓、轴性损害症状及运动功能总评分仍较对照组高。　结论:在病程相同的情况下,老年发病的PD患者其运动损害较普通年龄发病者更为严重。Objective: To analyze the characteristics of motor impairment in patients with Late-onset Parkinsons’sdisease(PD). Methods: forty-four PD patients with elderly onset and forty-four PD patients with middle age onset were recruited for this study. Motor impairment was evaluated by unified parkinson’s disease rating scale (UPDRS)and conditional logistic regression was used for the data analysis. Results:The patients with late onset had higher scores for bradykinesia(10.6±4.2 vs7.8±3.5, P< 0.01),axial impairment(10.7±3.8 vs 8.1±4.3, P<0.01),and total motor impairment(28.8± 7.9vs 22.9±6.6, P<0.01)than that in the control group. Four specific comorbidities that could affect the motor functions were more frequent in patients with late onset than the control patients, but even after adjusting for comorbidities,the late onset group still had highter scores of bradykinesia, axial impairment and total motor functions than that in the controls. Conclusion: Late-onet PD have more serious motor impairment than patients with middle age onset

关 键 词：帕金森病 老年发病 运动障碍 

分 类 号：R742.5[医药卫生—神经病学与精神病学]