采用脐血对新生儿进行地中海贫血诊断的临床研究  

Clinical study on diagnosis of the thalassemia to neonate by using umbilical blood.

作　　者：邱瑞霞[1] 

机构地区：[1]暨南大学医学院第五附属医院清远市人民医院,511500

出　　处：《中国优生与遗传杂志》2005年第3期71-72,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的　应用脐血对新生儿进行地中海贫血的筛查。方法　采用红细胞休克一管定量法及醋酸纤维素膜电泳 ,进行血红蛋白定量、定性分析。结果　在 1 4 38例脐血中 ,α -地贫的的遗传度是 1 2 .1 % ,β -地贫的的遗传度是 2 4 .1 % ,母亲遗传占 6 .81 % ,1家 3口均为地贫占 1 .6 % ,Bart′s水肿胎占 0 .6 3%。结论　应用脐血筛查地贫 ,方便、快捷 ,能有效检出α -地贫患儿 ,结果准确、可靠 ,可在临床推广应用。Objective: To using umbilical blood detect the thalassemia to neonate.Methods: Using simple tube red cell shock quantitative test and acetic acid cellulose membrane electrophoresis quantitative analysis to hemoglobin . Results: The heritability of α- thalassemia is 12.1%, β- thalassemia is 24.1%, mather heredity is 6.81%, all families attack thalassemia is 1.6%, Bart′s edema syndrome is 0.63%. Conclusion: Using umbilical blood detect the thalassemia to neonate can detect effectively α- thalassemia infant , results is convenient and quick and accurate and dependable.

关 键 词：脐血 地中海贫血 电泳 Bart’s 水肿胎 遗传度 

分 类 号：R725.5[医药卫生—儿科]