鼠原发性三叉神经痛下丘脑β内啡肽含量测定  

Determination of β-endorphin in hypothalamus of rat with primary trigeminal neuralgia

作　　者：刘红娟[1] 王文宇[1] 孙宏晨[2] 

机构地区：[1]吉林省人民医院口腔科,长春130021 [2]吉林大学口腔医学院口腔病理科

出　　处：《中华口腔医学杂志》2005年第2期154-155,共2页Chinese Journal of Stomatology

摘　　要：目的　检测鼠三叉神经痛脑组织中β内啡肽含量及其生理作用。方法　取Wister大鼠 37只,分为实验组 20只,生理盐水组 10只,空白对照组 7只。建立鼠三叉神经痛实验动物模型,采用放射免疫测定β内啡肽含量。结果　实验组明显低于生理盐水组和空白对照组,P<0 01。结论　脑组织中β内啡肽含量明显降低是引起鼠原发性三叉神经痛的重要原因之一。Objective To determine the level and the role of β endorphin in hypothalamus of rat with trigeminal neuralgia.Methods The animanl model of primary trigeminal neuralgia in rat was established,the contents of β endorphin were measured by radioimmunoassy techniques.Results The β endorphin of hypothalamus in experimental group was significantly lower than other groups ( P <0 01).Conclusions β endorphin may play important roles in primary trigeminal neuralgia.

关 键 词：鼠 原发性三叉神经痛 下丘脑 Β内啡肽 含量 测定 

分 类 号：R745.11[医药卫生—神经病学与精神病学]