中小负荷运动对心理应激大鼠免疫功能若干指标的影响  

The Effect of Low and Moderate Exercise on Immune Function in Rats After Mental Stress

作　　者：颜军[1] 尹剑春[2] 翟一飞[3] 孙开宏[4] 陈爱国[1] 

机构地区：[1]扬州大学体育学院,扬州225002 [2]淮阴师范学院体育系,淮安223001 [3]华东师范大学体育学院,上海200062 [4]扬州教育学院体育系,扬州225002

出　　处：《体育与科学》2005年第2期55-59,共5页Sports & Science

基　　金：江苏省教育厅自然科学研究指导性计划 (IK0 31 0 0 64)

摘　　要：为了探讨中小负荷运动对心理应激下大鼠心理神经免疫若干指标的影响及其调节机制 ,对 5 4只大鼠进行为期 8周的身体运动 ,并在身体运动后期施加心理应激 ,测定下丘脑及血清中β -EP、皮质酮、IL -1β和血浆T淋巴细胞亚群 (CD3 + 、CD4+ 、CD8+ )等指标的含量。实验结果表明 ,心理应激组的血清IL -1β水平显著低于对照组 ,CD3 + 、CD4+ 、CD8+ 虽无显著性变化 ,但有下降的趋势 ,而皮质酮、β -EP的含量明显高于对照组 ;与心理应激组相比 ,运动 +应激组的IL -1β水平和CD3 + 、CD4+ 数目显著升高 ,对CD8+ 的影响不显著 ,而 β -EP和皮质酮含量均有所下降。中等负荷身体运动在应激状态下对大鼠机体功能的保护非常显著 ,比小负荷运动更能提高机体应激的应对能力。To explore The effect of low and moderate exercise on plasma several i ndex of psychoneuroimmunology in rats after mental stress. SD rats were conducte d on exercise training for 8 weeks and exerted on mental stress in the later sta ge of training, β-EP、corticosterone、IL-1βand CD3+、 CD4+ 、CD8+ in pla sma we re measured.The result showed that, IL-1βin plasma are significantly lower than those in control group. the number of CD3+ 、CD4+ and CD8+ of mental stre ss gro up had not significant change, but had the lower trend.β-EP and corticosterone level are significantly higher than those of control. The IL-1βand CD3+、 CD4 + level of exercise +stress groups are higher than those in stress groups. Both c orticosterone andβ-EP are decrease from stress level. Low and medium exercise c an bring down the stress reaction and protect the neuroendocrine function under mental stress.

关 键 词：心理应激 身体运动 免疫功能 动物实验 Β-EP IL-1β 皮质酮 T淋巴细胞亚群 

分 类 号：G804.8[文化科学—运动人体科学]