早老素蛋白的研究进展  

Advances in the Research of Presenilins

作　　者：石琦[1] 李锋[2] 高晨[2] 周玉玲[1] 董小平[2] 

机构地区：[1]西安交通大学医学院,西安市710061 [2]中国疾病预防控制中心病毒病预防控制所,北京市100052

出　　处：《医学分子生物学杂志》2005年第2期108-110,122,共4页Journal of Medical Molecular Biology

基　　金：国家自然基金(No.30070038);国家自然科学基金重点项目(No.30130070);国家高技术研究发展计划(863计划)(No.2001AA215391);欧盟资助项目(QLRT 200001441)~~

摘　　要：早老素蛋白(presenilin.PS)的基因多态性与阿尔茨海默病(Alzheimer's disease,AD)发病关系密切。P5是具有多个跨膜区的膜蛋白,在神经细胞中表达最广泛,主要定位在内质网(endoplasmic reticulum,ER)。PS与Notch蛋白、sel-12及δ-catenin蛋白都有相关性,因此可能在一定程度上参与lin-12/Nocth、Wingless/Wnt信号传导途径。另外,P5可使Aβ42分泌增多,PS-2使神经细胞对凋亡刺激物敏感性增强,同此在AD的发生中起到重要作用。The Presenilin (PS) gene polymorphism is closely associated with Alzheimer's disease. PS is a membrane protein which has several transmembrane domains. It is mainly expressed in nerve system and then mostly localized in endoplasmic reticulum (ER. PS is related to Notch, sel-12 and δ-catenin, so it may be involved in lin-12/Nocth and Wingless/Wnt signal pathways. In addition, PS can increase the secretion of Aβ42 and PS-2 can lead to a sensitization to apoptotic stimuli. Therefore, PS plays a important role in the pathogenesis of AD.

关 键 词：阿尔茨海默病 早老素蛋白 细胞凋亡 

分 类 号：R749.1[医药卫生—神经病学与精神病学] Q51[医药卫生—临床医学]