多焦ERG对葛根素提高网脱术后视功能的疗效评价  

The effects of Puerarin on the attached retina followed by the operation of rhegmatogenous retinal detachment

作　　者：滕岩[1] 李莉[1] 董丽[1] 于旭辉[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院眼科,哈尔滨150001

出　　处：《中国实用眼科杂志》2005年第3期278-280,共3页Chinese Journal of Practical Ophthalmology

摘　　要：目的　应用多焦视网膜电图评价葛根素提高网脱术后视功能的作用。方法　将 2 0 0 2年 1 1月至 2 0 0 4年 4月 ,住院的孔源性视网膜脱离、经常规的视网膜脱离手术视网膜复位的病人 1 1 0例 1 1 0眼 ,随机分为两组 ,观察组静脉滴注葛根素注射液 50 0ml/d ,对照组静脉滴注奥多肽 (蛋白水解物 )注射液 2 0ml/d ,1 0～ 1 5天。治疗前后检测多焦视网膜电图 (mERG)评价视网膜的功能。观察指标 :治疗前后mERG4个象限的P1波平均象限反应密度 (QAP_1,nv/deg^2 ) ,P1波幅值 (AP_1,μv) ,N1波幅值 (AN_1,μv) ,P1波潜伏期 (TP_1,ms) ,N1波潜伏期 (TN_1,ms)数据结果均应用SPSS软件进行统计学处理。结果　观察组与对照组 ,年龄、网脱面积、治疗前视力均无明显差异 (P>0 . 0 5) ;治疗前观察组与对照组视网膜脱离象限mERG各值比较无明显差异 (P >0 .0 5) ;治疗后观察组网脱象限mERG各指标中 ,象限P1波幅值密度 (QA_1) ,P_1、N_1波幅值 (Ap_1、AN_1)均明显高于对照组 ,N_1波潜伏期明显短于对照组 ;观察组治疗前后网脱象限mERG各指标之差中 ,象限P1波幅值密度 (QAP1) ,P_1、N_1波幅值 (Ap_1、AN_1)均明显高于对照组。结论　葛根素有促进孔源性视网膜脱离术后复位视网膜功能恢复作用 ,多焦视网膜电图可以客观地评价。Objective Appling mERG to investigating the effect of puerarin on the reattached retina followed by the operation of rhegmatogenous retinal detachment.Methods The patients of RD that the retina had reattached in anatomy were randomly divided into two groups,puerarin for study and anduotai for control.The former postoperatively injected puerarin into veins 500mg a day and the later injected anduotai into veins 20mg a day.Both were treated for more than ten days.Multifocal ERG was used to evaluate the function of retina pre and post operatively.Results Preoperatively,multifocal ERG from the quadrant of the retina detached had no difference in both groups( P >0 05).Postoperatively,the value of m ERG in study was significantly increased( P <0 05).Conclusions Puerarin may have the effect on the functional recovery of retina.Multifocal electroretinography can be used to evaluated the visual function of the puerarin.

关 键 词：ERG 对照组 波幅 观察 葛根素 术后 治疗前后 象限 AN 结论 

分 类 号：R774[医药卫生—眼科] R779[医药卫生—临床医学]