F11R基因多态性与精神分裂症的关系  

Relationship between F11R gene polymorphism and schizophrenia

作　　者：陶然[1] 史杰萍[1] 郭英君[1] 贺晨[1] 张小娟[1] 于雅琴[1] 

机构地区：[1]吉林大学公共卫生学院基因组医学研究中心,吉林长春130021

出　　处：《吉林大学学报（医学版）》2005年第2期196-198,共3页Journal of Jilin University：Medicine Edition

基　　金：国家自然科学基金资助课题 (39970 16 5 )

摘　　要：目的 :探讨 1号染色体上 F11R基因多态性与精神分裂症的关系。方法 :采用聚合酶链式反应 -限制性内切酶片段长度多态性 (PCR- RFL P)的方法对 12 8例精神分裂症患者、 114例健康对照 1号染色体 F11R基因上的一个 SNP进行基因型检测 ,应用 SPSS统计学软件数据处理 ,并进行统计学分析。结果 :等位基因 A和 G的频数分布在病例组和对照组中无统计学意义 (χ2 =0 .4 98,P>0 .0 5 ) ;AA和 AG两种基因型频数分布在病例组和对照组中也无统计学意义 (χ2 =0 .5 33,P>0 .0 5 )。结论 :1号染色体上的 F11R基因可能不是精神分裂症的易感基因。Objective To investigate the relationship between F11R gene polymorphism on chromosome 1 and schizophrenia in Chinese population. Methods The PCR-RFLP method was conducted to examine the genotypes of F11R genes in 242 subjects including 128 patients with schizophrenia (case group) and 114 healthy controls (control group), and then the frequencies of genotype and allele of F11R gene were statistically computed. Results There were no remarkable differences of the frequency distributions of A and G of F11R gene between cases and controls (χ~2=0.498, P>0.05), and the frequency distributions of AA and AG had no markedly differences between cases and controls (χ~2=0.533, P>0.05). Conclusion The F11R gene on chromosome 1 may be not the susceptible gene of schizophrenia.

关 键 词：精神分裂症 多态现象(遗传学) 染色体 人 1对 F11R基因 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R596.3[医药卫生—临床医学]