实验性根尖周炎组织中CGRP免疫阳性纤维的变化  

Changes of CGRP-IR nerve fibers in experimental inflammation of periapical tissue

作　　者：姜文兰[1] 周杰[2] 林莉[2] 

机构地区：[1]辽宁省沈阳市第九人民医院,110024 [2]中国医科大学附属口腔医院

出　　处：《现代口腔医学杂志》2005年第2期177-179,共3页Journal of Modern Stomatology

摘　　要：目的观察根尖周炎时根尖周组织中CGRP免疫阳性纤维的变化。方法在大鼠双侧上颌第一磨牙开髓,分别观察8、15、35天,通过免疫组化法比较正常和炎症状态下根尖周组织中CGRP免疫阳性纤维的变化,然后进行图像分析阳性纤维密度。结果开髓8、15、35天根尖周组织中CGRP免疫阳性纤维增多,开髓15天组阳性纤维密度最高。结论CGRP参与了根尖周炎症的发生、发展过程。Objective To investigate the changes calcitonin gene-related peptide immunoreactive (CGRP-IR) nerve fibers of periapical tissue exhibit in the course of inflammation.Methods Pulp exposures were performed on the mandibular first molars of Wistar rats. At the 8~th ,15~th and 35~th day after the pulp exposure, the changes between the control group and inflammation group of periapical tissue were examined with immunocytochemical strain (SABC); the density of CGRP-IR nerve fibers were analyzed by Luzex-F microprojector analysis instrument.Results CGRP-IR nerve fibers in periapical tissue were increased after the pulp exposure. At the 8~th , 15~th and 35~th day, the CGRP positive fibers density were ~1.1043 ±~0.2459 , ~1.5265 ±~0.3147 , ~1.3423 ±~0.3165 , respectively. The CGRP-IR nerve fibers density was the highest at the 15~th day.Conclusion CGRP-IR nerve fibers may be involved in the initiation and development of periapical inflammation.

关 键 词：免疫阳性 CGRP 开髓 根尖周组织 阳性纤维 根尖周炎 实验性 密度 

分 类 号：R781.3[医药卫生—口腔医学]