老年人皮质下动脉硬化性脑病患者的CT分型与智能及神经心理障碍的关系(英文)  

CT classification of subcortical arterioselerotic encephalopathy in relation to intellectual and neuropsychological disturbance in the elderly

作　　者：王鲁妮[1] 刘泽[1] 冯德光[1] 戴波[1] 

机构地区：[1]解放军广州军区广州总医院干部内五科,广东省广州市510010

出　　处：《中国临床康复》2005年第9期202-203,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:皮质下动脉硬化性脑病(subcorticalarterioseleroticencephalopathy,SAE)临床以高血压、脑卒中和慢性进行性痴呆为主要表现,对其确切发病机制和早期评估普遍重视不足。目的:了解老年人SAE的智能及神经心理障碍与CT分型之间的关系,探讨对SAE的评估价值。设计:以患者为研究对象,病例分析。单位:一所军区总医院的内科。对象:1999-01/2002-12解放军广州军区广州总医院共收治老年SAE患者68例,其中男65例,女3例;年龄64～93岁,平均(75.8±8.1)岁。方法:以头颅CT扫描观察脑室周围低密度灶并按GOTO方法分型。测定智能障碍水平并进行神经心理测定,进行相关分析。主要观察指标:68例患者智能障碍水平,神经心理测定结果,头颅CT表现,头颅CT分型与智能障碍评分和神经心理得分的相关关系。结果:68例中91%(62/68)的患者有不同程度的智能障碍;100%可诊断为血管性痴呆;头颅CT显示100%的患者有脑室周围低密度灶,GO-TO分型Ⅰ型22例,Ⅱ型32例,Ⅲ型14例;头颅CT分型与智能障碍评分呈负相关,与神经心理得分呈正相关,相关系数分别为-0.83和0.75(P均<0.01)。结论:老年人SAE患者的头颅CT的GOTO分型分型与智能障碍和神经心理障碍有关。BACKGROUND:It is now know that the clinical presentations of subcortical arterioselerotic encephalopathy(SAE) could be mainly manifested by hypertension, stroke and chronic developed dementia, but there are very a few explorations on its definite pathogenesis and earlier assessment.OBJECTIVE:To investigate the correlation of CT classification of SAE with intellectual and neuropsycholohical disturbance,so as to explore the significance of CT classification of SAE to the assessment of SAE.DESIGN:Clinical case analysis based on patients.SETTING:A department of internal medicine in a military general hospital of Chinese PLA.PARTICIPANTS:From January 1999 to December 2002,totally 68 elders with confirmed SAE,received treatment at Guangzhou General Hospital of Guangzhou Military Area Command of Chinese PLA, included 65 males and 3 females,aged from 64 to 93 years old with the average age of(75.8± 8.1) years old took part in the study.METHODS:Low- density focus around ventricle were observed with skull CT scanning and classified according to GOTO classification. Meanwhile the intellectual test and neuropsycholohical test were carried out,and the correlative analysis was conducted.MAIN OUTCOME MEASURES:Intellectual test,neuropsycholohical test,skull CT scanning,and analysis of correlation of CT classification with scores of intellectual test and neuropsycholohical test. RESULTS:Of 68 patients,91% (62/68) was proved to have different degree intellectual obstacle,100% was found to be vascular dementia;and low- density focus around ventricle were proved to be existed in all patients with skull CT scanning,GOTO classification indicated that type Ⅰ was found in 22 patients,type Ⅱ in 32 patients and type Ⅲ in 14 patients;skull CT classification was negatively correlated with the scores of intellectual test and positively correlated with scores of neuropsychiological test,with the correlative coefficient of - 0.83 and 0.75 respectively(P < 0.01). CONCLUSION:GOTO classification of skull CT of SAE is related to intelle

关 键 词：脑动脉硬化 精神发育迟滞 神经心理学测验 体层摄影术 X线许算机 

分 类 号：R743.1[医药卫生—神经病学与精神病学]