建立局部脑血流量丧失指数公式评估脑动脉狭窄程度(英文)  

Assessment of cerebral arteriostenosis with regional cerebral blood flow loss index formula

作　　者：吴钢[1,2] 陆兵勋[3] 许国英[1] 郑依勇[1] 魏慧星[1] 

机构地区：[1]福建医科大学附属第一医院神经内科 [2]解放军第一军医大学南方医院神经内科,广东省广州市510515 [3]解放军第一军医大学南方医院神经内科

出　　处：《中国临床康复》2005年第9期232-234,共3页Chinese Journal of Clinical Rehabilitation

基　　金：福建省科技厅项目(2003Y038)~~

摘　　要：背景:经颅多普勒超声(TCD)频谱分析技术无法测量血管管径大小,因此,无法计算脑血流量的改变。在推导动脉狭窄指数公式中,发现动脉狭窄后局部脑血流量丧失指数(rCBFLI)的计算方法,试图为评估脑功能提供参考。目的:介绍一种根据TCD检查的资料推导出脑血流量丧失比率的计算公式。设计:以经TCD检查为大脑中动脉狭窄和正常人群为研究对象,回顾性研究。单位:一所大学医学的神经内科和一所军医大学医院的神经内科。对象:1994-10/2000-11福建医科大学附属第一医院神经内科住院及门诊TCD资料中大脑中动脉狭窄43例和1992-03/2000-09本院908例经TCD检查正常的资料。方法:研究分析31例一侧和12例双侧大脑中动脉(MCA)狭窄的TCD检查资料,推导出MCA狭窄的狭窄指数(STI)公式:STI=1-犤平均血流速度(Vm0)÷狭窄处平均血流速度(Vm1)犦·犤狭窄后脉动指数(PI1)÷正常脉动指数(PI0)犦,并推导出(PI1÷PI0)可能等于犤狭窄后血流量(Q1)÷正常血流量(Q0)犦,则:局部脑血流量丧失指数(rCBFLI)=犤1-(Q1÷Q0)犦·100%=犤1-(PI1÷PI0)犦·100%。主要观察指标:rCBFLI,STI和Vm的相关性,rCBFLI和STI的相关性。结果:采用rCBFLI公式计算出31例一侧MCA狭窄后的rCBFLI。采用Pearson法统计分析,得出31例一侧MCA狭窄的rCBFLI,STI与狭窄处平均血?BACKGROUND:Transcranial Doppler(TCD) spectrum analysis techniques cannot meas ure the diameters of blood vessels and therefore and not be used to calculate th e changes of brain blood flow.A formula was designed for regional cerebral blood flow loss index(rCBFLI) following arteriostenosis when arteriostenosis index fo rmula was deduced;the former may provide a reference to assess cerebral function . OBJECTIVE:To introduce the formula of cerebral blood flow loss ratio obtained basing on TCD results. DESIGN:Retrospective controlled study based on patients with cerebral middle arteriostenosis diagnosed with TCD and healthy people.SETTING:At the departments of neurology in a university hospital and in a mil itary medical university affiliated hospital of Chinese PLA. PARTICIPANTS:Between October 1994 and December 2000,43 patients who were conf irmed of arteriostenosis with TCD at outpatient or neurological ward of the Firs t Affiliated Hospital of Fujian Medical University were enrolled into this study ,and their TCD results were compared with 908 normal controls between March 1992 and September 2000. METHODS:Stenosis index(STI) formula was deduced from TCD results of 31 unilat eral and 12 bilateral stenoses at middle cerebral artery(MCA).STI=1 - [normal a verage blood velocity(Vm0) ÷ average blood velocity at stenosis(Vm1)]· [pulse index following stenosis(PI1)÷ normal pulse index(PI0)].Since(PI1÷ PI0) may be equal to [post- stenosis blood flow(Q1)÷ normal bl ood flow(Q0)], regional cerebral blood flow loss index is concluded as:(rCBFLI)= [1- (Q1÷ Q0)] · 100% =[1- (PI1÷ PI0)]· 100% . MAIN OUTCOME MEASURES:rCBFLI,relationship between STI and Vm,as well as betwe en rCBFLI and STI. RESULTS: rCBFLI formula was used to calculate the rCBFLI of 31 patients follo wing unilateral MCA stenosis.rCBFLI of these 31 patients was obtained by Pearson statistical analysis.STI was found to be related to the average blood velocity at stenosis with relative coefficient(Vm) of(r)=0.76(P< 0.001) and r=0.83 (P< 0. 001).r

关 键 词：超声检查 多普勒 经颅 脑动脉疾病 脑血管循环 

分 类 号：R743[医药卫生—神经病学与精神病学]