^(99)Tc^m-MDP与^(18)F-FDG显像对转移瘤探测价值的比较  

Comparison of ^(99)Tc^m-MDP and ^(18)F-FDG imaging in detecting metastases

作　　者：张燕燕[1] 李欣欣[1] 张松林[1] 毛远[1] 张卫方[1] 

机构地区：[1]北京大学第三医院核医学科,北京100083

出　　处：《中国医学影像技术》2005年第3期465-468,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的　对恶性肿瘤患者同时行99 Tcm-MDP、18 F-FDG显像,以探索两种显像在检测转移瘤方面的能力与特点。方法　对43例经病理证实的恶性肿瘤患者及1例结核患者在1个月内,分别进行99Tcm-MDP、18F FDG显像。结果　对骨转移瘤99Tcm-MDP与18F FDG检出灵敏度、特异性、准确性分别为 77%、77%,67%、91%,73%、82%。18 F FDG对恶性肿瘤转移灶的总检出灵敏度(包括骨及骨外)为 84%,较99 Tcm MDP高出 7%。结论　18 F FDG较99 Tcm-MDP对骨转移瘤更具特异性和准确性,因能发现早期骨外的软组织转移灶,故病灶隐匿者可先行18 F-FDG显像;由于二者对骨转移瘤检出灵敏度相同,且99Tcm MDP全身一次成像方便,故欲知有无骨转移瘤时,仍为一种准确经济的好方法。Objective To compare the ability of detecting metastases for two methods, the patients who illed with malignant tumor underwent examinations of ^(99)Tc^m-MDP (technetium-99m methylene diphosphate) and ^(18)F-FDG (^(18)F-fluoro-2-deoxy-D-glucose) imaging during a month. Methods Forty-three patients with malignant tumor and a tuberculosis patient that were confirmed by pathology underwent examination of ^(99)Tc^m-MDP and ^(18)F-FDG imaging. Results The sensitivity, specificity and accuracy for ^(99)Tc^m-MDP and ^(18)F-FDG imaging were 77% and 77%, 67% and 91%, 73% and 82% to detect the bone metastases respectively. But total sensitivity (including bone and out of bone) was 84% for ^(18)F-FDG imaging. It was 7% higher than ^(99)Tc^m-MDP. Conclusion ^(18)F-FDG examination should be adopted earlier if there is some information to suggest malignant tumor but focus to occult. Because ^(99)Tc^m-MDP imaging may have whole body bone scan in one time and may discover bone metastases sensitively and economically, so that is a good method for patient who doubted bone metastases.

关 键 词：^99TC^M-MDP ^18F-FDG 显像 转移瘤 

分 类 号：R730.44[医药卫生—肿瘤]