人乳头瘤病毒感染与宫颈癌前病变和宫颈癌关系的研究  

The Study on The Relationship Between HPV Infection and Cervical Cancer and Cervical Intraepithelial Neoplasia

作　　者：谢静[1] 乔惠珍[2] 王琳 马旭 

机构地区：[1]内蒙古自治区医院妇产科,内蒙古呼和浩特010017 [2]内蒙古医学院附属医院妇产科,内蒙古呼和浩特010050 [3]国家计生委科研所,北京100081

出　　处：《内蒙古医学杂志》2005年第2期118-121,共4页Inner Mongolia Medical Journal

摘　　要：目的 :探讨HPV感染与宫颈癌前病变及宫颈癌的关系。方法 :以聚合酶链反应 (PCR)和多重PCR法检测 75例宫颈癌、4 5例宫颈癌前病变、4 0例正常宫颈组织中HPV感染及型别分布状况。结果 :HPV总阳性率为 5 2 . 5 % ,HPV阳性率随宫颈病变的逐渐加重呈趋势性增加 (χ2 趋势 =5 9 811,P <0 . 0 1)。HPV感染率在不同临床分期及不同病理分级宫颈癌组织间无显著性差异 (P >0 . 0 5 )。宫颈癌组HPV16阳性率为 6. 1 3% ,宫颈癌前病变组为 2 6 . ,与宫颈癌前病变组相比 ,无显著性差异 (P >0 . 0 5 )。结论 :HPV感染是宫颈癌的主要致病因素 ,HPV16和宫颈癌密切相关 ,HPV感染对宫颈癌的进展及组织分化影响不大。Objective:To study the association between HPV infection and cervical cancer and cervical intraepithelial neoplasia (CIN).Methods:PCR and multiplex PCR were used to test infectious frequency and type distribution of HPV in 40 normal cervical tissues,45 CIN tissues and 75 cervical cancer tissues.Results:The positive rates of HPV was 52.5%,HPV positive rates increased with the seriousness of cervical lesions (χ2 trend=59 811,P<0 01).HPV positive rates have nocorrelation with clinical stage and histological grade of cervical cancer (P>0 05).The positive rates of HPV 16 in cervical cancer,CIN and normal cervix were 61.3%,26.7% and 2.5%,respectively (P<0 01).The positive rates of HPV 18,HPV 31 and HPV 33 in cervical cancer were no significant difference compared with CIN (P>0 05).Conclusion:HPV infection plays a central role in the development of cervical cancer,of which HPV 16 are closely associated with cervical cancer.HPV infection has nocorrelation with clinical stage and histological grade of cervical cancer.

关 键 词：人乳头瘤病毒 聚合酶链反应 宫颈癌 宫颈癌前病变 

分 类 号：R737.33[医药卫生—肿瘤] R730.26[医药卫生—临床医学]