粘膜相关淋巴瘤和结外弥漫大B细胞淋巴瘤临床病理特征和预后分析  

Clinicopathological Features and Prognosis of MALT Lymphoma and Extranodal Diffuse Large B-cell Lymphoma

作　　者：杨文秀[1] 李甘地[1] 周桥[1] 刘卫平[1] 张杰[1] 

机构地区：[1]四川大学华西医院病理科,成都市610041

出　　处：《中国肿瘤临床》2005年第6期304-307,共4页Chinese Journal of Clinical Oncology

基　　金：中华医学基金会基金资助(编号:CM B00-722);国家自然科学基金资助(编号:30370600)

摘　　要：目的:比较粘膜相关淋巴瘤和结外弥漫大B细胞淋巴瘤的临床病理特征和预后,探讨两类淋巴瘤的预后影响因素。方法:94例结外B细胞淋巴瘤(粘膜相关淋巴瘤62例,结外弥漫大B细胞淋巴瘤32例),经诊断复查后,收集其临床病理和随访资料,进行统计学分析。结果:两类淋巴瘤相比较,M ALT淋巴瘤发病的中位年龄、临床病理分期、复发率、淋巴结累及率和细胞增殖活性均偏低,5年生存率较高。94例结外B细胞淋巴瘤的生存影响因素分析:肿瘤细胞增殖指数>20%的患者生存状况较<20%的患者低,ⅠE期以上患者生存状况较ⅠE期患者差,伴有淋巴结累及的患者生存状况较无累及患者低。结论:粘膜相关淋巴瘤与结外弥漫大B细胞淋巴瘤在发病年龄、细胞增殖水平、临床分期、复发等临床病理特征上有明显差异。肿瘤细胞增殖活性、临床病理分期及淋巴结累及对两种淋巴瘤的生存状况和预后有明显影响。Objective: To compare the clinicopathological features of mucosa associated lymphoid tissue (MALT) and extranodal diffuse large B-cell lymphoma and investigate some factors associated with their prognosis. Methods: Ninety-four cases of extranodal B-cell lymphomas (including 62 cases of mucosa associated lymphoid tissue lymphoma and 32 cases of extranodal diffuse large B-cell lymphoma) were retrieved. The clinicopathological data about the cases were collected and follow-up study was done. Results: As compared to extranodal diffuse large B cell lymphoma, the incidence of mucosa- associated lymphoid tissue lymphoma was low with regard to the median age, staging, frequency of relapse, involvement of lymph node, and cellular proliferation index. The survival status was better in the patients showing a low cellular proliferation index (≤20%), stageⅠE and no involvement of lymph node, whereas the survival status was worse in those showing a higher cellular proliferation index ( >20%) and stage (aboveⅠE)as well as the involvement of lymph node. Conclusion: There is statistical difference between the mucosa associated lymphoid tissue lymphoma and the extranodal diffuse large B cell lymphoma in the aspects, i.e. the median age, cellular proliferation index, staging, involvement of lymph node, relapse rate and prognosis. The prognosis for both types of lymphomas relates to the cellular proliferation, staging and the involvement of lymph node.

关 键 词：粘膜相关淋巴瘤 弥漫大B细胞淋巴瘤 临床病理特征 预后 

分 类 号：R733.1[医药卫生—肿瘤]