血清CK-MB与晚期肿瘤患者心功能的相关性及其对预后的判断  

Relationship of Serum Level of Creatine Kinase of MB Type to Cardiac Function of Patients with Advanced Tumors and Its Prognostic Value

作　　者：吴晓明[1] 胡承章[1] 李宁[1] 朱继庆[1] 吴艳芳[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤医院综合科,北京100021

出　　处：《癌症》2005年第4期506-508,共3页Chinese Journal of Cancer

摘　　要：背景与目的:晚期肿瘤患者常并发心功能障碍,心功能的监测是晚期肿瘤患者临床观察的重要指标。血清肌酸激酶MB型(CK鄄MB)是心肌损伤的一种生化标志物,本研究旨在探讨血清CK鄄MB升高与晚期肿瘤患者心功能的相关性及临床预后价值。方法:以免疫抑制法测定血清CK鄄MB,观察组为34例血清CK鄄MB升高的晚期肿瘤患者,对照组为随机选择同期住院的34例无血清CK鄄MB升高的晚期肿瘤患者。结果:血清CK鄄MB升高与Ⅲ、Ⅳ级心功能不全呈显著正相关(P<0.05),观察组死亡率显著高于对照组(P<0.01)。血清CK鄄MB升高尤其多见于原发性肝癌和有肝脏转移的患者(P<0.05)。结论:血清CK鄄MB升高的患者心功能状况差、病情重、死亡率高。血清CK鄄MB升高可作为判定晚期肿瘤患者预后差的指标之一。BACKGROUND & OBJECTIVE: Patients with advanced tumors usually suffe r from cardiac dysfunction. Monitoring cardiac function is important for these p atients. Serum creatine kinase of MB type (CK-MB) is a biochemical marker of car diac damage. This study was to estimate relationship of serum level of CK-MB to cardiac function of patients with advanced tumors, and its prognostic value. MET HODS: Serum CK-MB in 68 patients with advanced tumors was detected by immunoinhi bition assay. Observation group was composed of 34 patients with elevated serum CK-MB. Control group was composed of 34 patients with normal serum CK-MB level. RESULTS: Incidence of cardiac insufficiency of grade Ⅲ-Ⅳ was significantly hig her in observation group than in control group (21 vs. 6, P < 0.05). Mortality o f observation group was significantly higher than that of control group (25 vs. 8, P < 0.01). Elevation of serum CK-MB was frequently found in patients with pri mary liver cancer or liver metastasis (P < 0.05). CONCLUSIONS: Patients with ele vated serum CK-MB often suffer from cardiac insufficiency, severe illness status , and have high mortality. Serum level of CK-MB may be a predictor of poor progn osis of patients with advanced tumors.

关 键 词：肿瘤 心功能不全 肌酸激酶 预后 

分 类 号：R730.4[医药卫生—肿瘤]