细胞间粘附分子-1在结肠癌淋巴转移中表达意义的研究  

Expression of Intercellular Adhesion Molecule-1 in Lymphatic Metastasis of Colon Cancer and Its Clinical Significance at Present

作　　者：郑辉[1] 王岩[1] 姚立杰[1] 

机构地区：[1]齐齐哈尔医学院解剖教研室,161042

出　　处：《齐齐哈尔医学院学报》2005年第1期5-6,共2页Journal of Qiqihar Medical University

摘　　要：　目的　研究结肠癌瘤体细胞间粘附分子-1(intercellular adhesion molecule-1,ICAM-1)的表达与结肠癌临床病理特征及其侵袭转移的关系。方法　采用免疫组化技术(S-P法)对 60 例结肠癌及15例远癌结肠组织标本中 ICAM-1 进行检测,分析 ICAM-1 的表达与结肠癌临床病理之间的关系。结果　结肠癌和远癌结肠组织中 ICAM-1的阳性表达率分别为70%(42/60)和20%(3/15),两者之间差异有显著性(P <0.01),组织 ICAM-1表达水平与结肠癌淋巴结转移、TNM分期密切相关。结论　检测结肠癌组织 ICAM-1的表达水平对评估淋巴结转移程度、TNM分期及结肠癌侵袭深度有较大意义, ICAM-1可能是反映结肠癌侵袭转移潜能的一个有效生物学指标。Objective This study was to determine the expression of ICAM-1(intercellular adhesion molecule-1) in patients with colon cancer and to elucidate the relation of its level with clinical characteristics and metastasis of colon cancer. Methods Immunohistochemical method was used to detect ICAM-1 expression in 60 patients with colon cancer and in 15 cases of colon tissue distal to cancer cell. Results The positive expression rates of ICAM-1 in colon cancer and colon tissue distal to cancer cell were 70%(42/60) and 20%(3/15) respectively, with significant difference (P<0.01).The intensity of ICAM-1 expression in tissue of colon cancer was correlated with lymph node metastasis and TNM stage. Conclusions Examination of ICAM-1 in colon cancer helps to evaluate the intensity of lymph node metastasis, TNM stage and prognosis of patients. ICAM-1 might be valuable markers in assessing invasion and metastasis potential of colon carcinoma.

关 键 词：结肠癌 ICAM-1 表达 结肠组织 癌侵袭 细胞间粘附分子-1 TNM分期 达意 意义 差异 

分 类 号：R735.35[医药卫生—肿瘤] R737[医药卫生—临床医学]