胆囊癌与妊娠关系的全人群病例对照研究  

Number of pregnancies and risk of gallbladder cancer:A population-based case- control study in Shanghai, China

作　　者：张学宏[1] 高玉堂[1] Asif Rashid 邓杰[1] 程家蓉[1] 刘恩菊[1] 邬恺[1] 孙璐[1] Gloria Gridley Ann W Hsing 

机构地区：[1]上海市肿瘤研究所,上海200032 [2]美国M.D.Anderson癌症中心 [3]美国国立癌症研究所

出　　处：《肿瘤》2005年第2期148-151,共4页Tumor

摘　　要：目的探讨胆囊癌与妊娠的关系.方法采用全人群病例对照研究,研究对象为1997年6月1日～2001年5月31日期间确诊、年龄在35～74岁的上海市区女性胆囊癌269例以及按年龄(5岁一组)频数配对的538名人群对照,采用非条件lo-gistic回归模型分析妊娠与胆囊癌的关系.结果胆囊癌合并胆石症者中,与妊娠次数≤2次者比较,妊娠次数(3次,4次,5次及≥6次)的各组调整OR分别为1.33(95%CI:0.59-2.99),1.34(95%CI:0.58-3.11),1.39(95%CI:0.57-3.43)和2.67(95%CI:1.12-6.41),趋势检验P=0.03.结论多次妊娠可能通过胆石症影响胆囊癌的发生,生育因素导致的女性体内雌、孕激素水平的升高可能在胆囊癌病因学中起一定的作用.Objective To investigate the relationship between number of pregnancies and risk of gallbladder cancer. Methods A population-based case-control study was conducted i n urban Shanghai from June 1, 1997 through May 31, 2001 involving interviews wit h 269 new cases of gallbladder cancer aged 35 to 74 years and 538 population con trols, frequency-matched to cases by age in five-years group. All subjects wer e interviewed in person by trained interviewers by use of a structured questionn aire. Unconditional logistic regression was used to calculate the adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Results Compared with women ever having pregnancies less than 2 times, higher numbers of pregnancies (3 times,4 times,5 times and ≥6 times) we re related to an increased risk of gallbladder cancer with adjusted ORs of 1.33 (95%CI: 0.59-2.99),1.34 (95%CI: 0.58-3.11), 1.39 (95%CI: 0.57-3.43)and 2.67 ( 95%CI: 1.12-6.41), respectively (P for trend=0.03). Conclusion Increasing number of pregnancies appears to increase the risk of gallbladder cancer probably through gallstone disease. And increase d exposure to endogenous estrogens and progesterone may play a role in the etiol ogy of gallbladder cancer.

关 键 词：肿瘤/流行病学 胆石症 妊娠率 病例对照研究 

分 类 号：R735.8[医药卫生—肿瘤] R73-31[医药卫生—临床医学]