大肠癌组织中P-gp、GSTπ、Topo-Ⅱ的表达及临床意义  

Expression and clinical significance of P-gp、GST-π and Topo-Ⅱ in colorectal carcinoma

作　　者：阙挺 杨莉芳 王文卿 郁宝铭[2] 

机构地区：[1]上海邮电医院,上海200040 [2]上海第二医科大学附属瑞金医院,上海200020

出　　处：《肿瘤》2005年第2期163-165,共3页Tumor

摘　　要：目的　探讨大肠癌组织中耐药基因旦白P -gp、GST -π和Topo- Ⅱ的表达与病理组织学类型、Dukes分期、淋巴结转移的相关性及其在化疗中的临床指导意义。方法　应用免疫组织化学方法检测53例手术切除的结直肠癌组织中P -gp、GST- π和Topo Ⅱ的表达。结果　结直肠癌组织中P- gp、GST- π和Topo -Ⅱ的阳性率分别为79.25%、54.72%和56.60%。GST -π的表达与结直肠癌的组织学类型相关,而P gp的表达与淋巴结转移相关。Topo- Ⅱ的表达与本组临床病理参数均无相关性。结论　根据P- gp、GST -π和Topo Ⅱ的不同表达,结合各自不同的耐药机制,对肿瘤的化疗药物和方案选择具有重要的临床意义。Objective To investigate the expression of P-gp、G ST-π and Topo-Ⅱ, and the correlation with histopathological grading, Dukes s taging, lymph node metastasis and the clinical significance for chemotherapy in colorectal carcinoma. Methods Fifty-three cases of tissue samp les of colorectal carcinoma were examined for expression of P-gp、GST-π and T opo-Ⅱby immunohistochemistry. Results The positive expression rates of P-gp、GST-π and Topo-Ⅱ were 79.25%、54.72% and 56.60% respectivel y. GST-π expression was correlated with degree of differentiation, while P-gp expression was correlated with lymph node metastases, but the correlation of To po-Ⅱexpression with these clinical pathological parameters was not verified. Conclusion According to different expression of P-gp、GST-π a nd Topo-Ⅱcombined with their mechanisms of drug resistance, the important clin ical significance is obvious to the choice of drugs and plan in colorectal carci noma chemotherapy.

关 键 词：结肠直肠肿瘤 P-糖旦白类 谷胱甘肽转移酶类 DNA拓扑异构酶Ⅱ型 免疫组织化学 

分 类 号：R735.34[医药卫生—肿瘤]