帕金森病伽码刀治疗疗效追踪  

Follow-up study of Gamma knife radiosurgery in treatment of Parkinson' s disease.

作　　者：杨纶先[1] 蔺春玲[1] 张建军[1] 常义[2] 孔洁[2] 陈永严[2] 赵鹏来[2] 

机构地区：[1]新疆伊犁州友谊医院,835000 [2]南京医科大学附属脑科医院

出　　处：《临床神经外科杂志》2005年第1期28-30,共3页Journal of Clinical Neurosurgery

摘　　要：目的探讨帕金森病(PD)伽玛刀治疗的远期疗效方法对20例服药无效或不能耐受药物副作用的PD患者行伽玛刀治疗,并进行了3-5年的随访。结果失访2例,其余18例中显效3例;进步6例:无效9例,远期总有效率50%。结论对于药效不佳的PD患者可考虑伽玛刀治疗,宜注意选择好适应证及有效靶点;术中磁共振成像仅能做到靶点的解剖学定位,不能克服个体解剖差异达到生理学或功能学的定位,这可能是伽玛刀治疗PD疗效欠佳的主要原因。Objective To explore the long-term effectiveness of Gamma knife in treatment of Parkinson's disease (PD). Methods 20 patients with PD who took medicine invalid or could not stand the side-effect,were performed Gamma knife and followed up from 3 to 5 years. Rusults Of 20 cases,2 lost follow-up,3 were apparent effect,6 were advancement and 9 had no effect. General availability ratio was 50% .Conclusions Patients with PD who dose inefficiently or couldn't stand medieme side-effect may be considered the treatment of Gamma knife. Adaptive sign and effective target should be ehoosen suitably Magnetir Resonance Imaging (MRI) could only locate target in anatomy, and not in physiology or in function, because MRI couldn't overcome individual anatome difference.That may be the chief cause of bad curative effect in the treatment ot PD by Gamma knife.

关 键 词：帕金森病 伽玛刀 治疗 疗效观察 

分 类 号：R742.5[医药卫生—神经病学与精神病学]