多肿瘤标志物蛋白芯片检测对原发性肺癌的诊断价值  

Diagnostic Value of Multi-tumor Markers Protein Biochip Detection for Primary Pulmonary Cancer

作　　者：徐峰坡[1] 吴翼伟[1] 李清茹[1] 法逸华[1] 蔡广谦 

机构地区：[1]苏州大学附属第一医院核医学科,江苏苏州215006 [2]数康生物科技有限公司,上海200233

出　　处：《标记免疫分析与临床》2005年第1期1-3,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：研究多肿瘤标志物蛋白芯片检测对原发性肺癌的诊断价值。本文应用蛋白芯片检测 45 例原发性肺癌患者血清中12项肿瘤标志物: AFP、CEA、神经元特异性烯醇化酶(NSE)、CA125、CA15 3、CA242、CA19 9、PSA、游离前列腺特异性抗原(f PSA)、铁蛋白(FER)、β HCG及人生长激素(HGH)。阳性率由高至低顺序为FER(42 2%), CEA(35 6%), CA125(24 4%), CA15 3(17 8%), CA242(13 3%), CA19 9(11 1%),β HCG(8 9%), HGH(6 7%), NSE (4 4%), AFP (0), f PSA (0 )及 PSA ( 0 )。除 FER 外, 有一项指标异常占57 8%。蛋白芯片检测对原发性肺癌的多指标联检阳性率明显较单一指标高,对原发性肺癌的诊断有较高的临床应用价值。To evaluate the diagnostic value of multi-tumor markers protein biochip detection for primary pulmonary cancer, 12 tumor markers including AFP, CEA, NSE, CA125, CA15-3, CA242, CA19-9,PSA, f-PSA, FER, β-HCG and HGH were measured by the protein biochip in the serum of 45 primary pulmonary cancer patients.Positive rate of tumor markers was FER(42.2%), CEA(35.6%), CA125(24.4%), CA15-3(17.8%), CA242(13.3%), CA19-9(11.1%), β-HCG(8.9%),HGH( 6.7%), NSE(4.4%), AFP(0), f-PSA(0) and PSA(0), respectively. The rate of patients with one abnorma indicator was 57.8% except FER. The positive rate using multi-tumor markers protein biochip detection was significantly higher than that of single tumor marker detective method, and this detection can be used for the diagnosis of patients with primary pulmonary cancer.

关 键 词：肿瘤标志物 蛋白芯片 原发性肺癌 诊断 

分 类 号：R734.2[医药卫生—肿瘤]