人三叉神经节细胞体外培养及对HSV-1感染敏感性的实验研究  

AN EXPERIMENTAL STUDY ON CULTIVATION OF HUMAN TRIGEMINAL GANGLIONIC CELL IN VITRO AND ITS SENSITIVITY TO INFECTION OF HERPES SIMPLEX VIRUS TYPE 1

作　　者：谢立信[1] 董晓光[1] 祝寿荣[1] 张德如[1] Bryan M Gebhardt Herbert E Kaufman 

机构地区：[1]山东省医学科学院眼科研究所 [2]美国鲁易斯安那州立大学眼科中心

出　　处：《眼科学报》1994年第2期67-70,共4页Eye Science

摘　　要：首次报告了人三叉神经节Trigeminal Ganglian(TG)三种原代培养细胞在体外对单纯疱疹病毒1型(HSV-1)Mckrae株感染后的不同时相的敏感性实验研究。结果表明人TG中的神经节细胞对HSV-1感染最敏感,HSV—1抗原可以在其胞浆及胞核中迅速出现。成纤维细胞和胶质细胞也有部分感染现象。这种结果提示TG中的神经节细胞很可能是HSV-1主要的潜伏感染细胞。We firstly report an experimental study on the sensitivity of primary cultural human trigeminal ganglionic cells infected by herpes simplex virus type l(HSV-l) in different time-points. The results indicate that the neuron of human trigeminal ganglia is the most sensitive cell type, the antigen of HSV-1 replicates rapidly within the cytoplasm and cell nucleus, the fibroblasts and glia cells are infected partly by the virus. Therefore, perhaps the neuron is the main harboring cell type. Eye Science

关 键 词：三叉神经节 单纯疱疹病毒 细胞培养 角膜感染 

分 类 号：R361.3[医药卫生—病理学] R772.202[医药卫生—基础医学]