短节段Barrett食管临床研究  

A clinical study of short-segment Barrett's esophagus

作　　者：徐晓蓉[1] 李兆申[1] 邹多武[1] 许国铭[1] 孙振兴[1] 尹宁[1] 

机构地区：[1]第二军医大学附属长海医院消化科,上海200433

出　　处：《中华消化杂志》2004年第6期326-328,共3页Chinese Journal of Digestion

摘　　要：目的　探讨短节段Barrett食管 (SSBE)的临床特征、诊治、随访及其可能发病机制。方法　回顾分析 5 2例经内镜和病理确诊的SSBE ,重点为内镜特征、病理学改变、食管动力检查结果、内镜复查及疗效观察。结果　SSBE内镜下以岛型最多见占 86 .5 % ,常规病理证实的特异型肠上皮化生占1 5 .4 % ,1 1例患者行 2 4h食管 pH和胆汁联合监测及食管测压 ,72 .7%存在异常。 2 1例患者行氩离子凝固术等内镜介入治疗 ,短期内复查 1 5例SSBE消退。 4 9例复查胃镜者未发现食管癌变。结论　SSBE发生与胃酸和胆汁反流相关 ,内镜下以岛型常见 ,其肠化生。Objective To investigate the clinical features, management, surveillance and possible pathophysiology of short segment Barrett's esophagus (SSBE).Methods Fifty two cases of SSBE identified by endoscopy and pathology were enrolled in this retrospective study. The endoscopic manifestations, pathological changes, esophageal motor function, management and follow up results were assessed.Results The island pattern was most prominent type accounting for 86.5%, and specialized intestinal metaplasia (SIM) was found in 15.4% of patients with routing H E stain. Abnormal motor function were showed in 8 of 11 cases(72.7%) who received 24 hs esophageal pH and bilirubin monitoring and esophageal manomery. Argon plasma coagulation therapy was carried out in 21 cases and SSBE ablation was achieved in 15 cases based on shor term follow up result. No esophageal adenocarcinoma was found in 49 patients revisited.Conclusions SSBE is associated with abnormal gastroesophageal acid and bile reflux. Island pattern is the most common endoscopic appearance. Specialized intestinal metaplasia and dysplasia may be less frequent in patients with SSBE.

关 键 词：BARRETT食管 内镜下 复查 患者 节段 临床研究 肠上皮化生 短节 异常 发现 

分 类 号：R735.1[医药卫生—肿瘤]