用大鼠血钙法测定降钙素生物效价的探讨  

Biological Assay of Calcitonin by Blood Calcium Determination in Rats

作　　者：钱德明[1] 沈根全[1] 柯若伦[1] 

机构地区：[1]中国药品生物制品检定所

出　　处：《药物分析杂志》1994年第3期30-34,共5页Chinese Journal of Pharmaceutical Analysis

摘　　要：本文报道了用大白鼠血钙法测定降钙素生物效价的方法。选定适当的大鼠血钙测定方法，测定了大白鼠的正常血钙值。探讨了不同给药途径及各种实验条件、剂量和反应的关系等。测定了４批降钙素注射液和喷鼻剂的生物效价。This study describes a method for the bioassay of Calcitonin by estimating the blood calcium levels in Rats. The normal blood calcium value of rats is determined by an available method. The different route of adminstration, experiment condition and dose-response relationship are discussed. There is an insignificant difference between potency restimated by subcutaneous and intravenous injections based on 3 calcitonin preparations of different types.

关 键 词：降钙素 效价测定 大鼠 血钙测定 

分 类 号：R392－33[医药卫生—免疫学]