鼻腔黏膜活检诊断恶性黑色素瘤6例临床病理分析  

Clinicopathologic characteristics of mucosal melanomas in nasal cavity: a report of 6 biopsied cases and review of literature

作　　者：王文亮[1] 张传山[1] 张静[1] 郭华章[1] 程虹[1] 马福成[1] 

机构地区：[1]第四军医大学西京医院病理科,西安710033

出　　处：《诊断病理学杂志》2004年第6期386-388,I101,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的　报道 6例鼻腔黏膜恶性黑色素瘤 ,分析其病理组织形态学特点及临床表现。方法　组织形态学结合免疫组化 ,对 6例鼻腔黏膜恶性黑色素瘤的临床表现、病理形态学特点进行探讨。结果　本组鼻腔黏膜恶性黑色素瘤病例均为中老年患者 ;病变由多种类型细胞组成 ,如梭形细胞、上皮样细胞和未分化细胞等 ;瘤组织呈巢状、结节状等方式分布 ;免疫组化染色显示病变组织表达S 10 0、HMB4 5和Pan melanin。结论　鼻腔黏膜恶性黑色素瘤易误诊为其他鼻腔原发性肿瘤 ,导致临床处理不当 ,延误治疗 ;较之皮肤黑色素瘤 ,鼻腔黏膜恶性黑色素瘤更具有侵袭性 。Objective To report 6 cases of primary mucosal melanomas in the nasal cavity and to discuss the histological and clinical features. Methods The clinical characteristics and histological features of mucosal melanomas of the nasal cavity were discussed in combination with immunohistochemical studies. Results Six patients, who were elder men, were found to have mucosal melanomas of the nasal cavity. Histologically, the tumors were composed of a variety of cell types (such as epithelioid, spindled, undifferentiated) tissue patterns. Immunohistochemical staining showed the tumors were positive for S\|100, HMB45 and Pan\|melanin. Conclusion Primary nasal mucosal melanoma is a rare tumor that is frequently confused with other malignancies,resulting in inappropriate clinical management. As a consequence, the diagnosis is often best confirmed by immunohistochemical studies. To compare with melanoma in the skin, it usually follows an aggressive course.

关 键 词：鼻腔黏膜 恶性黑色素瘤 诊断 临床病理分析 活检 临床表现 原发性肿瘤 分化细胞 形态学特点 结节 

分 类 号：R739[医药卫生—肿瘤] R765[医药卫生—临床医学]