大汗腺肿瘤凝集素亲和组化研究  

Affinity Histochemistry Study of Apocrine Sweat Gland Tumors Lectins

作　　者：李建军[1] 朱翠凤[1] 佟菊贞[2] 程滨珠[1] 钟绮丽[1] 马刚[1] 

机构地区：[1]北京大学深圳医院皮肤科,深圳518036 [2]中山大学附一院皮肤科,广州510080

出　　处：《中国中西医结合皮肤性病学杂志》2005年第1期4-6,共3页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

摘　　要：目的探讨皮肤大汗腺肿瘤细胞表面凝集素受体的变化规律及意义。方法用17种生物素化凝集素检测了21例大汗腺良恶性肿瘤细胞表面凝集素受体的表达情况。结果大汗腺恶性肿瘤细胞表面WGA、ECL、STL、PNA、RCA-Ⅰ、RCA-Ⅱ阳性率较低,与良性肿瘤相比差异有显著性,DBA、BSL-Ⅰ、UEA-Ⅰ、SBA在部分Paget’s病细胞阳性。生乳头汗管囊腺瘤、生乳头汗腺腺瘤、大汗腺混合瘤在PNA、RCA-I、ECL阳性着染相似。结论大汗腺良恶性肿瘤细胞膜表面凝集素受体发生了有意义的变化,某些凝集素受体的变化可能有助于大汗腺肿瘤的诊断和鉴别诊断。Objective To investigate the location and distribution of lectin-receptors in the apocrine sweat gland tumors. Methods The expression of the lectin-receptors of twenty-one cases of apocrine sweat gland tumors were detected by ABC method and seventeen kinds of lectins. Results There are statistically significant differences between the positive rates of lectin-receptors of benign and malignant apocrine sweat gland tumors for WGA,ECL,STL,PNA,RCA-Ⅰ and RCA-Ⅱ. Expression of DBA, BSL-Ⅰ,UEA-Ⅰ and SBA were observed in part cases of Paget's disease. Similar expressions of PNA,RCA-Ⅰ and ECL were observed in Syringocystdenoma papilliferum, Hidradenoma papilliferum and Aprine mixed tumor. Conclusion The expression of lectin-receptor markedly changed the cell of apocrine sweat gland tumors and aided to diagnosis and differentical diagnosis in apocrine sweat gland tumors.

关 键 词：大汗腺 良恶性肿瘤 凝集素受体 恶性肿瘤细胞 头汗 阳性 混合瘤 PNA RCA 生物素 

分 类 号：R739.5[医药卫生—肿瘤] R622[医药卫生—临床医学]