轻度认知损害和阿尔茨海默病的听觉诱发电位与P_(300)检查的性别差异  

Sex differences in brain stem auditory evoked potentials and P_(300) examination in patients with mild cognitive impairment and Alzheimer's disease

作　　者：陈炜[1] 王建琴[2] 张玲菊[2] 

机构地区：[1]浙江大学医学院附属邵逸夫医院,浙江杭州310016 [2]浙江大学医学院附属第一医院,浙江杭州310003

出　　处：《浙江大学学报（医学版）》2005年第2期172-176,180,共6页Journal of Zhejiang University(Medical Sciences)

基　　金：浙江省教育厅科研基金(20010526)资助项目

摘　　要：目的比较性别对阿尔茨海默病(AD)、轻度认知损害(MCI)的脑干听觉诱发电位(BAEP)、事件相关电位(ERP)P300的影响。方法对38例MCI、26例AD患者、20例健康老年人(HC)进行BAEP和P300检查,根据性别的不同,进行组间和组内的比较。结果组内BAEP比较,MCI组在左侧、波潜伏期差异有显著性(P<0.01);HC组在左侧、波潜伏期差异有显著性(P<0.01);AD组组内比较,差异无显著性;P300比较,MCI潜伏期女性比男性延长,差异有显著性(P<0.01);AD和HC组差异无显著性。组间BAEP比较,AD与MCI仅男性左侧、差异有显著性。AD与HC比较,男性在左侧、～和右侧波,女性在左右两侧～差异有显著性。MCI与HC比较,男性在左侧、和右侧、、波,女性在右侧、、波差异有显著性。P300检查发现,男性AD的潜伏期比MCI显著延长。AD和HC比较,无论男女在潜伏期的Fz、Cz、Pz点差异有显著性。MCI与HC比较,女性在潜伏期的Fz、Cz、Pz点,差异有显著性。结论性别对MCI的BAEP和P300检查均有影响,而对AD检查未显示明显的影响。相同性别的AD、MCI和HC的BAEP和P300的表现也有不同,可能对三者的鉴别有意义。Objective: To compare the sex differences on brain stem auditory evoked potentials (BAEP) and P_~300 in the elderly patients with mild cognitive impairment (MCI) and the patients with Alzheimer's disease(AD). Methods: Thirty-eight elderly patients with MCI,26 cases of AD and 20 health controls (HC) were examined with BAEP,P_~300 . Sex difference of the variables was compared inter-and intra-groups. Results: Significant sex ~diffe- ~rences of BAEP were found in the latency period wave Ⅲ,Ⅴof left side in the MCI group(P<0.01),in the latency period wave Ⅳ,Ⅴof left side in HC group(P<0.01),and no such differences were found in AD group.The females had longer latency period in P_~300 measurement than males in MCI group(P<0.01),but there were no significant differences within AD or HC groups .The males showed significant differences in wave Ⅰ,Ⅱ in left side between the MCI and AD groups.The males also showed significant difference in wave Ⅰ,Ⅲ~Ⅴin left side,wave Ⅳ in right side between AD and HC groups,and so did the females in wave Ⅰ~Ⅴ in both sides.The males had significant difference in the left wave Ⅲ,Ⅳ and right waveⅠ,Ⅳ,Ⅴ between MCI and HC groups,and so did the females in right side wave Ⅰ,Ⅱ,Ⅴ.In P_~300 ,longer latency waves were found in AD group than in MCI group.Both sexes showed significant differences in the latency of Fz,Cz,Pz between AD and HC groups,but no significant differences were found in the latency of Fz,Cz,Pz in the females between the MCI and HC groups. Conclusion: Sex ~diffe- ~rences were found in the examination of both BAEP and P_~300 in MCI group,but not in AD group.The people of same sex have different expression of BAEP and P_~300 among MCI,AD and HC groups,suggesting the sex difference should be considered in the differential diagnosis. [

关 键 词：性别因素 轻度认知障碍 阿尔茨海默病 事件相关电位 P300 听觉诱发电位 

分 类 号：R749.1[医药卫生—神经病学与精神病学]