一种白僵菌代谢产物提取物抗抑郁作用的研究  

Effects of bioactive compoundsfrom entomogenous fungi on depression mouse models

作　　者：周兰兰[1] 明亮[1] 马传庚[1] 樊美珍[2] 程燕[1] 江勤[1] 

机构地区：[1]安徽医科大学药理教研室,安徽合肥230032 [2]安徽农业大学虫生真菌研究所,安徽合肥230032

出　　处：《中国药理学通报》2005年第3期358-360,共3页Chinese Pharmacological Bulletin

基　　金：安徽省教育厅科学基金资助项目(No2001KJ130);安徽省科技厅自然科学基金资助项目(No44415)

摘　　要：目的研究一种白僵菌代谢产物提取物(BCEF)的抗抑郁作用。方法采用未预知的慢性应激实验、育亨宾毒性实验、5羟色胺酸诱导甩头实验等多种模型研究BCEF抗实验性抑郁作用及可能的作用机制。结果慢性刺激d10、d21后BCEF50mg·kg-1可使慢性应激大鼠水平得分与垂直得分显著增加;BCEF(100mg·kg-1,ig,qd×14d)可升高育亨宾给药后24h的小鼠死亡率;BCEF50、100mg·kg-1可明显增加5羟色胺酸诱导甩头小鼠的甩头次数。结论BCEF在多种抑郁模型上具有一定的抗抑郁作用,可能与增强NE、5HT能神经系统有关。Aim To study the antidepressant effects of bioactive compounds from entomogenous fungi(BCEF) in mouse models of depression. Methods The antidepressant effects of Bioactive compounds from entomogenous fungi was examined on the chronic unpredictable stress test, yohimbine induced lethality test, and 5-HTP induced head-twitches test. Results BCEF(50 mg·kg^-1 , ig, qd×21 d)could significantly increase the crossing and rearing score in open-field test. After administration yohimbine 1 h, BCEF 100 mg·kg^-1 group mice mortality rate rising rapidly; BCEF(50,100 mg·kg^-1 ) could distinctly increase the head-twitch number in the 5-HTP induced head-twitches test. Conclusion BCEF has antidepressant effects in depression mouse models. The mechanisms of its antidepressant effects may be related with the reinforcement of central monoamine neurotransmitter especially to 5-HT and NE nerves system.

关 键 词：虫生真菌 白僵菌 抑郁 模型 单胺递质 

分 类 号：R-332[医药卫生] R379