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作 者:杨灵澜[1] 叶萍[1] 马莉[1] 秦蓉晖[1] 程斌中
机构地区:[1]山大学光华口腔医学院,510060
出 处:《实用口腔医学杂志》2005年第2期210-213,共4页Journal of Practical Stomatology
基 金:国家自然科学基金 ( 30371539 );广东省医学科研基金(A2003243)
摘 要:目的:建立口腔扁平苔藓(OLP)组织移植动物模型。方法:将人非糜烂型OLP病损移植到严重联合免疫缺陷(SCID)小鼠的舌腹和背部,动态观察移植物的生长情况及组织病理学特征的改变。结果:SCID小鼠舌腹和背部的OLP移植物生长良好。移植物组织病理学表现为移植后第 1周基底层部分液化变性,表皮下淋巴细胞弥散分布;第 2周基底层液化变性基本消失,表皮下大部分淋巴细胞消失。结论: OLP组织移植物的上皮组织生长良好,但第 2周起若干病理特征逐渐消失,尚需进一步改进移植方法。Objective:To establish an animal model of oral lichen planus (OLP). Methods:Human non-erosive OLP lesion tissue was surgically transplanted into dorsal hypoderm or tongue abdomen in 10 severe combined immunodeficiency (SCID) mice, thereafter, growth and possible alterations of histopathological characteristics of the xenografts were observed for 2 weeks. Results:All the xenografts transplanted into dorsal hypoderm or tongue abdomen healed well.Partial liquefaction and subepithelial lymphocytes diffuse infiltration were observed in epithelial basement membrane in the first week after transplantation. During the subsequent week, the degenerated moiety was hardly to be seen, and the number of subepithelial lymphocytes was gradually decreased. Conclusions:The epithelia of OLP xenografts grow well in SCID mice but can not keep its histopathological features.
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